{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:32:56Z","timestamp":1777260776186,"version":"3.51.4"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[2002,5,20]],"date-time":"2002-05-20T00:00:00Z","timestamp":1021852800000},"content-version":"unspecified","delay-in-days":261,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>To determine how a progressive loss of photoreceptor cells \nand the concomitant loss of glutamatergic input to second-order \nneurons can affect inner-retinal signaling, glutamate receptor \nexpression was analyzed in the Royal College of Surgeons (RCS) \nrat, an animal model of retinitis pigmentosa. Immunohistochemistry \nwas performed on retinal sections of RCS rats and congenic controls \nbetween postnatal (P) day 3 and the aged adult (up to P350) \nusing specific antibodies against N-methyl-D-aspartate (NMDA) \nsubunits. All NMDA subunits (NR1, NR2A\u20132D) were expressed \nin control and dystrophic retinas at all ages, and distinct \npatterns of labeling were found in horizontal cells, subpopulations \nof amacrine cells and ganglion cells, as well as in the outer \nand inner plexiform layer (IPL). NR1 immunoreactivity in the \ninner plexiform layer of adult control retinas was concentrated \nin two distinct bands, indicating a synaptic localization of \nNMDA receptors in the OFF and ON signal pathways. In the RCS \nretina, these bands of NR1 immunoreactivity in the IPL were \nmuch weaker in animals older than P40. In parallel, NR2B \nimmunoreactivity in the outer plexiform layer (OPL) of RCS rats \nwas always reduced compared to controls and vanished between \nP40 and P120. The most striking alteration observed in the \ndegenerating retina, however, was a strong expression of NR1 \nimmunoreactivity in M\u00fcller cell processes in the inner \nretina which was not observed in control animals and which was \npresent prior to any visible sign of photoreceptor degeneration. \nThe results suggest functional changes in glutamatergic receptor \nsignaling in the dystrophic retina and a possible involvement \nof M\u00fcller cells in early processes of this disease.<\/jats:p>","DOI":"10.1017\/s0952523801185111","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T22:09:45Z","timestamp":1039644585000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Alterations in NMDA receptor expression during retinal \ndegeneration in the RCS rat"],"prefix":"10.48130","volume":"18","author":[{"given":"TATIANA","family":"GR\u00dcNDER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KONRAD","family":"KOHLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELKE","family":"GUENTHER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2002,5,20]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523801185111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:00:58Z","timestamp":1735848058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523801185111\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0952523801185111"],"URL":"https:\/\/doi.org\/10.1017\/s0952523801185111","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"Cambridge University Press 2011","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}