{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:15:02Z","timestamp":1778019302571,"version":"3.51.4"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"3","license":[{"start":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000},"content-version":"unspecified","delay-in-days":127,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>We investigated the effects of group II metabotropic glutamate \nreceptor (mGluR) activation on excitatory synaptic transmission \nin the salamander retinal slice preparation. The group II selective \nagonists DCG-IV and LY354740 reduced light-evoked excitatory \npostsynaptic currents (EPSCs) in ganglion cells. To determine \nthe synaptic basis of this effect, we also recorded from bipolar \ncells and horizontal cells. In ON bipolar cells, DCG-IV increased \nthe inward current in darkness but did not affect the peak current \nat light onset. In OFF bipolar cells and horizontal cells, DCG-IV \nhad the opposite effect, reducing the inward current in darkness. \nGiven the opposite polarities of these two classes of synapses, \nour results suggest that group II mGluRs act presynaptically \nto reduce glutamate release from photoreceptors. To determine \nwhether DCG-IV affected rods or cones, we applied light stimuli \nthat selectively activate each type of photoreceptor. In horizontal \ncells, most of which receive mixed synaptic input from rods \nand cones, DCG-IV reduced rod-driven EPSCs evoked by 470-nm \nstimuli and cone-driven EPSCs elicited by 700-nm stimuli in \nthe presence of a rod-saturating background. Thus, activation \nof group II mGluRs reduced rod- and cone-mediated glutamate \nrelease. Our results suggest that group II mGluRs could mediate \nfeedback by which extracellular glutamate inhibits glutamate \nrelease from photoreceptor terminals.<\/jats:p>","DOI":"10.1017\/s0952523802192054","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T22:10:44Z","timestamp":1039644644000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":18,"title":["Activation of group II metabotropic glutamate receptors inhibits \nglutamate release from salamander retinal photoreceptors"],"prefix":"10.48130","volume":"19","author":[{"given":"MATTHEW H.","family":"HIGGS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER D.","family":"LUKASIEWICZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2002,9,5]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523802192054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:01:11Z","timestamp":1735848071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523802192054\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0952523802192054"],"URL":"https:\/\/doi.org\/10.1017\/s0952523802192054","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2002 Cambridge University Press","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}