{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:40:22Z","timestamp":1735882822585,"version":"3.32.0"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[2002,11,12]],"date-time":"2002-11-12T00:00:00Z","timestamp":1037059200000},"content-version":"unspecified","delay-in-days":72,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>Axonal regeneration of retinal ganglion cells (RGCs) into a \nnormal or pre-degenerated peripheral nerve graft after an optic \nnerve pre-lesion was investigated. A pre-lesion performed 1\u20132 \nweeks before a second lesion has been shown to enhance axonal \nregeneration in peripheral nerves (PN) but not in optic nerves \n(ON) in mammals. The lack of such a beneficial pre-lesion effect \nmay be due to the long delay (1\u20136 weeks) between the two \nlesions since RGCs and their axons degenerate rapidly 1\u20132 \nweeks following axotomy in adult rodents. The present study \nexamined the effects of the proximal and distal ON pre-lesions \nwith a shortened delay (0\u20138 days) on axonal regeneration \nof RGCs through a normal or pre-degenerated PN graft. The ON \nof adult hamsters was transected intraorbitally at 2 mm (proximal \nlesion) or intracranially at 7 mm (distal lesion) from the optic \ndisc. The pre-lesioned ON was re-transected at 0.5 mm from the \ndisc after 0, 1, 2, 4, or 8 days and a normal or a pre-degenerated \nPN graft was attached onto the ocular stump. The number of RGCs \nregenerating their injured axons into the PN graft was estimated \nby retrograde labeling with FluoroGold 4 weeks after grafting. \nThe number of regenerating RGCs decreased significantly when \nthe delay-time increased in animals with both the ON pre-lesions \n(proximal or distal) compared to control animals without an \nON pre-lesion. The proximal ON pre-lesion significantly reduced \nthe number of regenerating RGCs after a delay of 8 days in \ncomparison with the distal lesion. However, this adverse effect \ncan be overcome, to some degree, by a pre-degenerated PN graft \napplied 2, 4, or 8 days after the distal ON pre-lesion enhanced \nmore RGCs to regenerate than the normal PN graft. Thus, in order \nto obtain the highest number of regenerating RGCs, a \npre-degenerated PN should be grafted immediately after an ON \nlesion.<\/jats:p>","DOI":"10.1017\/s0952523802195113","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T22:11:51Z","timestamp":1039644711000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Axonal regeneration of retinal ganglion cells after optic \nnerve pre-lesions and attachment of normal or pre-degenerated \nperipheral nerve grafts"],"prefix":"10.48130","volume":"19","author":[{"given":"SI-WEI","family":"YOU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KULDIP S.","family":"BEDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HENRY K.","family":"YIP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KWOK-FAI","family":"SO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2002,11,12]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523802195113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:01:35Z","timestamp":1735848095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523802195113\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0952523802195113"],"URL":"https:\/\/doi.org\/10.1017\/s0952523802195113","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"type":"print","value":"0952-5238"},{"type":"electronic","value":"1469-8714"}],"subject":[],"published":{"date-parts":[[2002,9]]},"assertion":[{"value":"2002 Cambridge University Press","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}