{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:17:42Z","timestamp":1791955062400,"version":"4.3.4"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"2","license":[{"start":{"date-parts":[[2003,6,26]],"date-time":"2003-06-26T00:00:00Z","timestamp":1056585600000},"content-version":"unspecified","delay-in-days":117,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>To determine whether the photoreceptors change structurally and \nfunctionally during aging, and to analyze whether pigmentation in the \nretinal pigment epithelium might be a contributing factor. Young, \nadult, and aged C57BL\/6 and Balb\/c mice (1, 4, and 17 months of \nage) were housed under a 12-h light\/12-h dark cycle, with an \nambient light intensity at the eye level of the mice of 85 \u00b1 18 \nlux. Scotopic single-flash and photopic-flicker electroretinograms \n(ERGs) after complete dark adaptation were used to assess rod and cone \nfunction, respectively. Numbers of rod photoreceptors were counted in \nplastic sections, and rhodopsin levels were measured using absorption \ndifference spectrophotometry. Numbers and types of cones were \ndetermined using lectin staining in retinal flatmounts and \ncone-specific antibodies in radial frozen sections. Young pigmented \nC57BL\/6 and nonpigmented Balb\/c mice had similar numbers of \nrods. In both mouse strains, there was an overall decline in rod \nphotoreceptor number during aging, which was more pronounced in albino \nmice. Rod cell numbers correlated with a drop in the overall amount of \nrhodopsin and a reduction in the maximum <jats:italic>a<\/jats:italic>-wave of the rod \nERG. The number of short-wavelength cones was unaffected by age and \npigmentation, whereas an age-related decline was observed in \nmid-wavelength (MWL) cones in albino, but not in pigmented mice. In \ncontrast, MWL cone function was reduced during aging in both strains.<\/jats:p>","DOI":"10.1017\/s0952523803202108","type":"journal-article","created":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T18:54:43Z","timestamp":1067885683000},"page":"211-220","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":118,"title":["Structure\u2013function analysis of rods and cones in juvenile, \nadult, and aged C57BL\/6 and Balb\/c mice"],"prefix":"10.48130","volume":"20","author":[{"given":"JEFFREY","family":"GRESH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICE W.","family":"GOLETZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSALIE K.","family":"CROUCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BAERBEL","family":"ROHRER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27968","published-online":{"date-parts":[[2003,6,26]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523803202108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:01:46Z","timestamp":1735848106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523803202108\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S0952523803202108"],"URL":"https:\/\/doi.org\/10.1017\/s0952523803202108","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]},"assertion":[{"name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}