{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:27:36Z","timestamp":1765279656437,"version":"3.32.0"},"reference-count":42,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"unspecified","delay-in-days":96,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>The genetic locus for incomplete congenital stationary night blindness \n(CSNB2) has been identified as the CACNA1f gene, encoding the \n\u03b1<jats:sub>1F<\/jats:sub> calcium channel subunit, a member of the L-type family \nof calcium channels. The electroretinogram associated with CSNB2 \nimplicates \u03b1<jats:sub>1F<\/jats:sub> in synaptic transmission between retinal \nphotoreceptors and bipolar cells. Using a recently developed monoclonal \nantibody to \u03b1<jats:sub>1F<\/jats:sub>, we localize the channel to ribbon active \nzones in rod photoreceptor terminals of the mouse retina, supporting a \nrole for \u03b1<jats:sub>1F<\/jats:sub> in mediating glutamate release from rods. \nDetergent extraction experiments indicate that \u03b1<jats:sub>1F<\/jats:sub> is part \nof a detergent-resistant active zone complex, which also includes the \nsynaptic ribbons. Comparison of native mouse rod calcium currents with \nrecombinant \u03b1<jats:sub>1F<\/jats:sub> currents reveals that the \ncurrent\u2013voltage relationship for the native current is shifted \napproximately 30 mV to more hyperpolarized potentials than for the \nrecombinant \u03b1<jats:sub>1F<\/jats:sub> current, suggesting modulation of the \nnative channel by intracellular factors. Lastly, we present evidence for \nL-type \u03b1<jats:sub>1D<\/jats:sub> calcium channel subunits in cone terminals of \nthe mouse retina. The presence of \u03b1<jats:sub>1D<\/jats:sub> channels in cones may \nexplain the residual visual abilities of individuals with CSNB2.<\/jats:p>","DOI":"10.1017\/s0952523805225038","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T18:13:27Z","timestamp":1208801607000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":92,"title":["Photoreceptor calcium channels: Insight from night blindness"],"prefix":"10.48130","volume":"22","author":[{"given":"CATHERINE W.","family":"MORGANS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILIPPA R.","family":"BAYLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICHOLAS W.","family":"OESCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GAOYING","family":"REN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAKSHMI","family":"AKILESWARAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. ROWLAND","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"S0952523805225038_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00159-8"},{"key":"S0952523805225038_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00086-2"},{"key":"S0952523805225038_ref039","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-68447-3_6"},{"key":"S0952523805225038_ref006","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10459"},{"key":"S0952523805225038_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902210103"},{"key":"S0952523805225038_ref024","unstructured":"Morgans, C.W. (2001).Localization of the {alpha}1F calcium channel subunit in the ratretina.Investigative Ophthalmology and Visual Science 42,2414\u20132418."},{"key":"S0952523805225038_ref026","doi-asserted-by":"crossref","unstructured":"Morgans, C.W. , El Far, O. , Berntson, A. , Wassle, H. , & Taylor, W.R. (1998).Calcium extrusion from mammalian photoreceptor terminals.Journal of Neuroscience 18,2467\u20132474.","DOI":"10.1523\/JNEUROSCI.18-07-02467.1998"},{"key":"S0952523805225038_ref036","unstructured":"Tremblay, F. , De Becker, I. , Cheung, C. , & Laroche, G. (1996).Visual evoked potentials with crossed asymmetry in incompletecongenital stationary night blindness.Investigative Ophthalmology and Visual Science 37,1783\u20131792."},{"key":"S0952523805225038_ref010","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10658"},{"key":"S0952523805225038_ref042","doi-asserted-by":"crossref","unstructured":"Yagi, T. & Macleish, P.R. (1994).Ionic conductances of monkey solitary cone inner segments.Journal of Neurophysiology 71,656\u2013665.","DOI":"10.1152\/jn.1994.71.2.656"},{"key":"S0952523805225038_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00822-X"},{"key":"S0952523805225038_ref037","doi-asserted-by":"crossref","unstructured":"Tsukamoto, Y. , Morigiwa, K. , Ueda, M. , & Sterling, P. (2001).Microcircuits for night vision in mouse retina.Journal of Neuroscience 21,8616\u20138623.","DOI":"10.1523\/JNEUROSCI.21-21-08616.2001"},{"key":"S0952523805225038_ref028","unstructured":"Orton, N. , Mansergh, F. , Vessey, J. , Lalonde, M. , Tremblay, F. , Barnes, S. , Rancourt, D. , Stell, W. , & Bech-Hansen, N. (2004).Mutation of the calcium channel gene cacna1f disrupts calciumsignaling and synaptic transmission in the mouse retina.IOVS 2004; 45:ARVO Abstract 2507."},{"key":"S0952523805225038_ref027","unstructured":"Morgans, C.W. , Gaughwin, P. , & Maleszka, R. (2001).Expression of the alpha1F calcium channel subunit by photoreceptorsin the rat retina.Molecular Vision 7,202\u2013209."},{"key":"S0952523805225038_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80116-4"},{"key":"S0952523805225038_ref019","doi-asserted-by":"crossref","unstructured":"Koschak, A. , Reimer, D. , Walter, D. , Hoda, J. , Heinzle, T. , Grabner, M. , & Striessnig, J. (2003).Cav1.4alpha1 subunits can form slowly inactivatingdihydropyridine-sensitive L-type Ca2+ channels lackingCa2+-dependent inactivation.Journal of Neuroscience 23,6041\u20136049.","DOI":"10.1523\/JNEUROSCI.23-14-06041.2003"},{"key":"S0952523805225038_ref030","unstructured":"Ruether, K. , Apfelstedt-Sylla, E. , & Zrenner, E. (1993).Clinical findings in patients with congenital stationary nightblindness of the Schubert-Bornschein type.German Journal of Ophthalmology 2,429\u2013435."},{"key":"S0952523805225038_ref034","doi-asserted-by":"crossref","unstructured":"Strom, T.M. , Nyakatura, G. , Apfelstedt-Sylla, E. , Hellebrand, H. , Lorenz, B. , Weber, B.H.F. , Wutz, K. , Gutwillinger, N. , Ruther, K. , Drescher, B. , Sauer, C. , Zrenner, E. , Meitinger, T. , Rosenthal, A. , & Meindl, A. (1998).An L-type calcium-channel gene mutated in incomplete X-linkedcongenital stationary night blindness.Nature Genetics 19,260\u2013263.","DOI":"10.1038\/940"},{"key":"S0952523805225038_ref025","doi-asserted-by":"crossref","unstructured":"Morgans, C.W. , Brandst\u00c4tter, J.H. , Kellerman, J. , Betz, H. , & W\u00e4ssle, H. (1996).A SNARE complex containing syntaxin 3 is present in ribbon synapsesof the retina.Journal of Neuroscience 16,6713\u20136721.","DOI":"10.1523\/JNEUROSCI.16-21-06713.1996"},{"key":"S0952523805225038_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(90)90127-7"},{"key":"S0952523805225038_ref016","doi-asserted-by":"crossref","unstructured":"Haeseleer, F. , Imanishi, Y. , Maeda, T. , Possin, D. , Maeda, A. , Lee, A. , Rieke, F. , & Palczewski, K. (2004).Essential role of Ca2+-binding protein 4, a Cav1.4channel regulator, in photoreceptor synaptic function.Nature Neuroscience 7,1079\u20131087.","DOI":"10.1038\/nn1320"},{"key":"S0952523805225038_ref035","doi-asserted-by":"crossref","unstructured":"Taylor, W.R. & Morgans, C.W. (1998).Localization and properties of voltage-gated calcium channels incone photoreceptors of Tupaia belangeri .Visual Neuroscience 15,541\u2013552.","DOI":"10.1017\/S0952523898153142"},{"key":"S0952523805225038_ref008","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00793.x"},{"key":"S0952523805225038_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00535-9"},{"key":"S0952523805225038_ref032","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754386"},{"key":"S0952523805225038_ref021","doi-asserted-by":"crossref","unstructured":"Michna, M. , Knirsch, M. , Hoda, J.-C. , Muenkner, S. , Langer, P. , Platzer, J. , Striessnig, J. , & Engel, J. (2003).Cav1.3 (alpha1D) Ca2+ currents in neonatal outer haircells of mice.Journal of Physiology (London) 553,747\u2013758.","DOI":"10.1113\/jphysiol.2003.053256"},{"key":"S0952523805225038_ref004","doi-asserted-by":"crossref","unstructured":"Bech-Hansen, N.T. , Naylor, M.J. , Maybaum, T.A. , Pearce, W.G. , Koop, B. , Fishman, G.A. , Mets, M. , Musarella, M.A. , & Boycott, K.M. (1998).Loss-of-function mutations in a calcium-channel \u03b11-subunit genein Xp11.23 cause incomplete X-linked congenital stationary nightblindness.Nature Genetics 19,264\u2013267.","DOI":"10.1038\/947"},{"key":"S0952523805225038_ref001","unstructured":"Ball, S.L. , Powers, P.A. , Shin, H.-S. , Morgans, C.W. , Peachey, N.S. , & Gregg, R.G. (2002).Role of the beta2 subunit of voltage-dependent calcium channels inthe retinal outer plexiform layer.Investigative Ophthalmology and Visual Science 43,1595\u20131603."},{"key":"S0952523805225038_ref023","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00719.x"},{"key":"S0952523805225038_ref041","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.5.621"},{"key":"S0952523805225038_ref009","doi-asserted-by":"crossref","unstructured":"Brandt, A. , Striessnig, J. , & Moser, T. (2003).CaV1.3 Channels are essential for development and presynapticactivity of cochlear inner hair cells.Journal of Neuroscience 23,10832\u201310840.","DOI":"10.1523\/JNEUROSCI.23-34-10832.2003"},{"key":"S0952523805225038_ref033","doi-asserted-by":"crossref","unstructured":"Schneeweis, D.M. & Schnapf, J.L. (1999).The photovoltage of macaque cone photoreceptors: adaptation, noise,and kinetics.Journal of Neuroscience 19,1203\u20131216.","DOI":"10.1523\/JNEUROSCI.19-04-01203.1999"},{"key":"S0952523805225038_ref014","unstructured":"Fei, Y. (2003).Development of the cone photoreceptor mosaic in the mouse retinarevealed by fluorescent cones in transgenic mice.Molecular Vision 9,31\u201342."},{"key":"S0952523805225038_ref040","doi-asserted-by":"publisher","DOI":"10.1126\/science.7832825"},{"key":"S0952523805225038_ref020","doi-asserted-by":"crossref","unstructured":"McRory, J. , Hamid, J. , Doering, C. , Garcia, E. , Parker, R. , Hamming, K. , Chen, L. , Hildebrand, M. , Beedle, A. , Feldcamp, L. , Zamponi, G. , & Snutch, T. (2004).The CACNA1F gene encodes an L-type calcium channel with uniquebiophysical properties and tissue distribution.Journal of Neuroscience 24,1707\u20131718.","DOI":"10.1523\/JNEUROSCI.4846-03.2004"},{"key":"S0952523805225038_ref022","doi-asserted-by":"crossref","unstructured":"Miyake, Y. , Yagasaki, K. , Horiguchi, M. , Kawase, Y. , & Kanda, T. (1986).Congenital stationary night blindness with negativeelectroretinogram. A new classification.Archives in Ophthalmology 104,1013\u20131020.","DOI":"10.1001\/archopht.1986.01050190071042"},{"key":"S0952523805225038_ref038","doi-asserted-by":"publisher","DOI":"10.1038\/41580"},{"key":"S0952523805225038_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523804215048"},{"key":"S0952523805225038_ref002","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.94.4.719"},{"key":"S0952523805225038_ref012","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1344"},{"key":"S0952523805225038_ref003","doi-asserted-by":"crossref","unstructured":"Baumann, L. , Gerstner, A. , Zong, X. , Biel, M. , & Wahl-Schott, C. (2004).Functional characterization of the L-type Ca2+ channelCav1.4 1 from mouse retina.Investigative Ophthalmology and Visual Science 45,708\u2013713.","DOI":"10.1167\/iovs.03-0937"},{"key":"S0952523805225038_ref017","doi-asserted-by":"crossref","unstructured":"Hoda, J. , Zaghetto, F. , Koschak, A. , & Striessnig, J. (2005).Congenital stationary night blindness type 2 mutations S229P, G369D,L1068P, and W1440X alter channel gating or functional expression of Cav1.4L-type Ca2+ channels.Journal of Neuroscience 25,252\u2013259.","DOI":"10.1523\/JNEUROSCI.3054-04.2005"}],"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523805225038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:03:17Z","timestamp":1735848197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523805225038\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0952523805225038"],"URL":"https:\/\/doi.org\/10.1017\/s0952523805225038","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"type":"print","value":"0952-5238"},{"type":"electronic","value":"1469-8714"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"2005 Cambridge University Press","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}