{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:30:28Z","timestamp":1791275428399,"version":"4.1.0"},"reference-count":87,"publisher":"Maximum Academic Press","issue":"1","license":[{"start":{"date-parts":[[2006,3,9]],"date-time":"2006-03-09T00:00:00Z","timestamp":1141862400000},"content-version":"unspecified","delay-in-days":67,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Glutamate release from photoreceptor terminals is controlled by voltage-dependent calcium channels (VDCCs). In humans, mutations in the<jats:italic>Cacna1f<\/jats:italic>gene, encoding the \u03b1<jats:sub>1F<\/jats:sub>subunit of VDCCs, underlie the incomplete form of X-linked congenital stationary night blindness (CSNB2). These mutations impair synaptic transmission from rod and cone photoreceptors to bipolar cells. Here, we report anatomical and functional characterizations of the retina in the<jats:italic>nob2<\/jats:italic>(<jats:italic>no b-wave 2<\/jats:italic>) mouse, a naturally occurring mutant caused by a null mutation in<jats:italic>Cacna1f<\/jats:italic>. Not surprisingly, the<jats:italic>b<\/jats:italic>-waves of both the light- and dark-adapted electroretinogram are abnormal in<jats:italic>nob2<\/jats:italic>mice. The outer plexiform layer (OPL) is disorganized, with extension of ectopic neurites through the outer nuclear layer that originate from rod bipolar and horizontal cells, but not from hyperpolarizing bipolar cells. These ectopic neurites continue to express mGluR6, which is frequently associated with profiles that label with the presynaptic marker Ribeye, indicating potential points of ectopic synapse formation. However, the morphology of the presynaptic Ribeye-positive profiles is abnormal. While cone pedicles are present their morphology also appears compromised. Characterizations of visual responses in retinal ganglion cells<jats:italic>in vivo<\/jats:italic>, under photopic conditions, demonstrate that ON-center cells have a reduced dynamic range, although their basic center-surround organization is retained; no alteration in the responses of OFF-center cells was evident. These results indicate that<jats:italic>nob2<\/jats:italic>mice are a valuable model in which to explore the pathophysiological mechanisms associated with<jats:italic>Cacna1f<\/jats:italic>mutations causing CSNB2, and the subsequent effects on visual information processing. Further, the<jats:italic>nob2<\/jats:italic>mouse represents a model system in which to define the signals that guide synapse formation and\/or maintenance in the OPL.<\/jats:p>","DOI":"10.1017\/s095252380623102x","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T09:04:26Z","timestamp":1206954266000},"page":"11-24","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":164,"title":["The<i>nob2<\/i>mouse, a null mutation in<i>Cacna1f<\/i>: Anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses"],"prefix":"10.48130","volume":"23","author":[{"given":"BO","family":"CHANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN R.","family":"HECKENLIVELY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPA R.","family":"BAYLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICHOLAS C.","family":"BRECHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MURIEL T.","family":"DAVISSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORM L.","family":"HAWES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARLENE A.","family":"HIRANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALD E.","family":"HURD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKIHIRO","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRITT A.","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAUREEN A.","family":"MCCALL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATHERINE W.","family":"MORGANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEVE","family":"NUSINOWITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NEAL S.","family":"PEACHEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENNIS S.","family":"RICE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KIRSTAN A.","family":"VESSEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALD G.","family":"GREGG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27968","published-online":{"date-parts":[[2006,3,9]]},"reference":[{"key":"S095252380623102X_ref082","doi-asserted-by":"crossref","unstructured":"Wong, W.T. , Faulkner-Jones, B.E. , Sanes, J.R. , & Wong, R.O. (2000).Rapid dendritic remodeling in the developing retina: Dependence onneurotransmission and reciprocal regulation by Rac and Rho.Journal of Neuroscience 20,5024\u20135036.","DOI":"10.1523\/JNEUROSCI.20-13-05024.2000"},{"key":"S095252380623102X_ref024","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903010308"},{"key":"S095252380623102X_ref087","doi-asserted-by":"crossref","unstructured":"Zhang, N. & Townes-Anderson, E. (2002).Regulation of structural plasticity by different channel types inrod and cone photoreceptors.Journal of Neuroscience 22,7065\u20137079.","DOI":"10.1523\/JNEUROSCI.22-16-07065.2002"},{"key":"S095252380623102X_ref060","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380000242X"},{"key":"S095252380623102X_ref005","unstructured":"Baumann, L. , Gerstner, A. , Zong, X. , Biel, M. , & Wahl-Schott, C. (2004).Functional characterization of the L-type Ca2+ channelCav1.4 from mouse retina.Investigative Ophthalmology and Visual Science 45,708\u2013713."},{"key":"S095252380623102X_ref017","doi-asserted-by":"crossref","unstructured":"Dhingra, A. , Lyubarsky, A. , Jiang, M. , Pugh, E.N., Jr. , Birnbaumer, L. , Sterling, P. , & Vardi, N. (2000).The light response of ON bipolar neurons requiresG\u03b1O .Journal of Neuroscience 20,9053\u20139058.","DOI":"10.1523\/JNEUROSCI.20-24-09053.2000"},{"key":"S095252380623102X_ref040","unstructured":"Koschak, A. , Reimer, D. , Walter, D. , Hoda, J.C. , Heinzle, T. , Grabner, M. , & Striessnig, J. (2003).Cav1.4 \u03b11 subunits can form slowly inactivatingdihydropyridine-sensitive L-type Ca2+ channels lackingCa2+-dependent inactivation.Journal of Neuroscience 23,6041\u20136049."},{"key":"S095252380623102X_ref053","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(04)47012-5"},{"key":"S095252380623102X_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00086-2"},{"key":"S095252380623102X_ref052","unstructured":"Morgans, C.W. , Gaughwin, P. , & Maleszka, R. (2001).Expression of the \u03b11F calcium channel subunit byphotoreceptors in the rat retina.Molecular Vision 7,202\u2013209."},{"key":"S095252380623102X_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00146-8"},{"key":"S095252380623102X_ref031","doi-asserted-by":"crossref","unstructured":"Haverkamp, S. & W\u00e4ssle, H. (2000).Immunocytochemical analysis of the mouse retina.Journal of Comparative Neurology 424,1\u201323.","DOI":"10.1002\/1096-9861(20000814)424:1<1::AID-CNE1>3.0.CO;2-V"},{"key":"S095252380623102X_ref072","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.11.009"},{"key":"S095252380623102X_ref077","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200408157"},{"key":"S095252380623102X_ref028","unstructured":"Gregg, R.G. , Read, D.S. , Peachey, N.S. , Pardue, M.T. , & McCall, M.A. (2002).Photoreceptor voltage dependent calcium channels but not bipolarcell activity is required for normal ribbon synapse formation.Investigative Ophthalmology and Visual Science 43,ARVO E-abstract 831."},{"key":"S095252380623102X_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/s004390100461"},{"key":"S095252380623102X_ref019","doi-asserted-by":"crossref","unstructured":"Engert, F. & Bonhoeffer, T. (1999).Dendritic spine changes associated with hippocampal long-termsynaptic plasticity.Nature 399,66\u201370.","DOI":"10.1038\/19978"},{"key":"S095252380623102X_ref034","unstructured":"Hoda, J.-C. , Zaghetto, F. , Koschak, A. , & Striessnig, J. (2005).Congenital stationary night blindness type 2 mutations S229P, G369D,L1068P, and W1440X alter channel gating or functional expression ofCav1.4 L-type Ca2+ channels.Journal of Neuroscience 25,252\u2013259."},{"key":"S095252380623102X_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523803203059"},{"key":"S095252380623102X_ref016","doi-asserted-by":"crossref","unstructured":"Dhingra, A. , Jiang, M. , Wang, T.L. , Lyubarsky, A. , Savchenko, A. , Bar-Yehuda, T. , Sterling, P. , Birnbaumer, L. , & Vardi, N. (2002).Light response of retinal ON bipolar cells requires a specificsplice variant of G\u03b1O .Journal of Neuroscience 22,4878\u20134884.","DOI":"10.1523\/JNEUROSCI.22-12-04878.2002"},{"key":"S095252380623102X_ref003","unstructured":"Ball, S.L. , Powers, P.A. , Shin, H.S. , Morgans, C.W. , Peachey, N.S. , & Gregg, R.G. (2002).Role of the \u03b22 subunit of voltage-dependent calciumchannels in the retinal outer plexiform layer.Investigative Ophthalmology and Visual Science 43,1595\u20131603."},{"key":"S095252380623102X_ref059","doi-asserted-by":"publisher","DOI":"10.1038\/nature01781"},{"key":"S095252380623102X_ref062","unstructured":"Redburn, D.A. & Rowe-Rendleman, C. (1996).Developmental neurotransmitters. Signals for shaping neuronalcircuitry.Investigative Ophthalmology and Visual Science 37,1479\u20131482."},{"key":"S095252380623102X_ref047","doi-asserted-by":"crossref","unstructured":"McCall, M.A. , Lukasiewicz, P.D. , Gregg, R.G. , & Peachey, N.S. (2002).Elimination of the \u03c11 subunit abolishes GABA(C)receptor expression and alters visual processing in the mouseretina.Journal of Neuroscience 22,4163\u20134174.","DOI":"10.1523\/JNEUROSCI.22-10-04163.2002"},{"key":"S095252380623102X_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901560107"},{"key":"S095252380623102X_ref037","unstructured":"Jalkanen, R. , Mantyjarvi, M. , Tobias, R. , Alitalo, T. , & Bech-Hansen, N.T. (2004).X-linked cone\u2013rod dystrophy (COD4) in a Finnish family iscaused by mutation in CACNA1F.American Journal of Human Genetics 75,A2593."},{"key":"S095252380623102X_ref083","doi-asserted-by":"publisher","DOI":"10.1038\/85987"},{"key":"S095252380623102X_ref069","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00678-1"},{"key":"S095252380623102X_ref079","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00006-8"},{"key":"S095252380623102X_ref042","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-200106000-00015"},{"key":"S095252380623102X_ref033","unstructured":"Hirano, A.A. & Brecha, N.C. (2002).Expression of the neurokinin-3 (NK3) receptor in off-type conebipolar cells in mouse retina.Investigative Ophthalmology and Visual Science 43,ARVO E-abstract No. 736."},{"key":"S095252380623102X_ref030","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10491"},{"key":"S095252380623102X_ref013","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0741"},{"key":"S095252380623102X_ref021","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716515"},{"key":"S095252380623102X_ref074","doi-asserted-by":"crossref","unstructured":"Tagawa, Y. , Sawai, H. , Ueda, Y. , Tauchi, M. , & Nakanishi, S. (1999).Immunohistological studies of metabotropic glutamate receptorsubtype 6-deficient mice show no abnormality of retinal cell organizationand ganglion cell maturation.Journal of Neuroscience 19,2568\u20132579.","DOI":"10.1523\/JNEUROSCI.19-07-02568.1999"},{"key":"S095252380623102X_ref041","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1996.tb01562.x"},{"key":"S095252380623102X_ref055","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.7.1028"},{"key":"S095252380623102X_ref048","doi-asserted-by":"crossref","unstructured":"McRory, J. , Hamid, J. , Doering, C. , Garcia, E. , Parker, R. , Hamming, K. , Chen, L. , Hildebrand, M. , Beedle, A. , Feldcamp, L. , Zamponi, G. , & Snutch, T. (2004).The CACNA1F gene encodes an L-type calcium channel with uniquebiophysical properties and tissue distribution.Journal of Neuroscience 24,1707\u20131718.","DOI":"10.1523\/JNEUROSCI.4846-03.2004"},{"key":"S095252380623102X_ref070","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225129"},{"key":"S095252380623102X_ref045","doi-asserted-by":"publisher","DOI":"10.1016\/0278-4327(90)90013-8"},{"key":"S095252380623102X_ref085","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.04.002"},{"key":"S095252380623102X_ref054","doi-asserted-by":"crossref","unstructured":"Nachman-Clewner, M. , St. Jules, R. , & Townes-Anderson, E. (1999).L-type calcium channels in the photoreceptor ribbon synapse:Localization and role in plasticity.Journal of Comparative Neurology 415,1\u201316.","DOI":"10.1002\/(SICI)1096-9861(19991206)415:1<1::AID-CNE1>3.0.CO;2-G"},{"key":"S095252380623102X_ref043","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5409.1923"},{"key":"S095252380623102X_ref004","doi-asserted-by":"publisher","DOI":"10.1177\/38.9.2201738"},{"key":"S095252380623102X_ref068","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00159-8"},{"key":"S095252380623102X_ref075","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1323"},{"key":"S095252380623102X_ref084","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200828"},{"key":"S095252380623102X_ref056","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00217-3"},{"key":"S095252380623102X_ref015","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<88::AID-JNR9>3.0.CO;2-R"},{"key":"S095252380623102X_ref046","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90354-2"},{"key":"S095252380623102X_ref025","unstructured":"Gregg, R.G. , Lukasiewicz, P.D. , Peachey, N.S. , Sagdullaev, B.T. , & McCall, M.A. (2003b).Nyctalopin is required for signaling through depolarizing bipolarcells in the murine retina.Investigative Ophthalmology and Visual Science 44,ARVO E-abstract 4180."},{"key":"S095252380623102X_ref010","doi-asserted-by":"crossref","unstructured":"Buffone, G.J. & Darlington, G.J. (1985).Isolation of DNA from biological specimens without extraction withphenol.Clinical Chemistry 31,164\u2013165.","DOI":"10.1093\/clinchem\/31.1.164"},{"key":"S095252380623102X_ref071","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800002431"},{"key":"S095252380623102X_ref027","doi-asserted-by":"crossref","unstructured":"Gregg, R.G. , Mukhopadhyay, S. , Candille, S.I. , Ball, S.L. , Pardue, M.T. , McCall, M.A. , & Peachey, N.S. (2003a).Identification of the gene and the mutation responsible for thenob (no b-wave) phenotype.Investigative Ophthalmology and Visual Science 44,378\u2013384.","DOI":"10.1167\/iovs.02-0501"},{"key":"S095252380623102X_ref014","doi-asserted-by":"publisher","DOI":"10.1038\/341536a0"},{"key":"S095252380623102X_ref020","unstructured":"Fishman, G.A. , Birch, D.G. , Holder, G.E. , & Brigell, M.G. (2001).Electrophysiologic Testing in Disorders of the Retina, Optic Nerveand Visual Pathway.Second edition. San Francisco, California:American Academy of Ophthalmology."},{"key":"S095252380623102X_ref078","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00175-1"},{"key":"S095252380623102X_ref036","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2005.00987.x"},{"key":"S095252380623102X_ref049","doi-asserted-by":"crossref","unstructured":"Miyake, Y. , Yagasaki, K. , Horiguchi, M. , Kawase, Y. , & Kanda, T. (1986).Congenital stationary night blindness with negativeelectroretinogram. A new classification.Archives of Ophthalmology 104,1013\u20131020.","DOI":"10.1001\/archopht.1986.01050190071042"},{"key":"S095252380623102X_ref051","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225038"},{"key":"S095252380623102X_ref058","unstructured":"Pardue, M.T. , McCall, M.A. , LaVail, M.M. , Gregg, R.G. , & Peachey, N.S. (1998).A naturally-occurring mouse model of X-linked congenital stationarynight blindness.Investigative Ophthalmology and Visual Science 39,2443\u20132449."},{"key":"S095252380623102X_ref038","doi-asserted-by":"crossref","unstructured":"Jeon, C.J. , Strettoi, E. , & Masland, R.H. (1998).The major cell populations of the mouse retina.Journal of Neuroscience 18,8936\u20138946.","DOI":"10.1523\/JNEUROSCI.18-21-08936.1998"},{"key":"S095252380623102X_ref076","doi-asserted-by":"crossref","unstructured":"Taylor, W.R. & Morgans, C. (1998).Localization and properties of voltage-gated calcium channels incone photoreceptors of Tupaia belangeri .Visual Neuroscience 15,541\u2013552.","DOI":"10.1017\/S0952523898153142"},{"key":"S095252380623102X_ref008","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902210103"},{"key":"S095252380623102X_ref022","doi-asserted-by":"crossref","unstructured":"Grady, E.F. , Baluk, P. , B\u00f6hm, S. , Gamp, P.D. , Wong, H. , Payan, D.G. , Ansel, J. , Portbury, A.L. , Furness, J.B. , McDonald, D.M. , & Bunnett, N.W. (1996).Characterization of antisera specific to NK1, NK2, and NK3neurokinin receptors and their utilization to localize receptors in therat gastrointestinal tract.Journal of Neuroscience 16,6975\u20136986.","DOI":"10.1523\/JNEUROSCI.16-21-06975.1996"},{"key":"S095252380623102X_ref026","unstructured":"Gregg, R.G. , McCall, M.A. , & Peachey, N.S. (2005).Bipolar specific expression of nyctalopin fusion gene rescues nob-wave phenotype in nob mice.Investigative Ophthalmology and Visual Science 46,ARVO E-abstract 3554."},{"key":"S095252380623102X_ref001","unstructured":"Ball, S.L. , McEnery, M. , & Gregg, R.G. (2004).Voltage gated calcium channel subunit composition and distributionin the retina.Investigative Ophthalmology and Visual Science 45,E-abstract 5423."},{"key":"S095252380623102X_ref006","unstructured":"Bech-Hansen, N.T. , Naylor, M.J. , Maybaum, T.A. , Pearce, W.G. , Koop, B. , Fishman, G.A. , Mets, M. , Musarella, M.A. , & Boycott, K.M. (1998).Loss-of-function mutations in a calcium-channel\u03b11-subunit gene in Xp11.23 cause incomplete X-linkedcongenital stationary night blindness.Nature Genetics 19,264\u2013267."},{"key":"S095252380623102X_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/90489"},{"key":"S095252380623102X_ref063","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800009408"},{"key":"S095252380623102X_ref073","doi-asserted-by":"crossref","unstructured":"Strom, T.M. , Nyakatura, G. , Apfelstedt-Sylla, E. , Hellebrand, H. , Lorenz, B. , Weber, B.H. , Wutz, K. , Gutwillinger, N. , R\u00fcther, K. , Drescher, B. , Sauer, C. , Zrenner, E. , Meitinger, T. , Rosenthal, A. , & Meindl, A. (1998).An L-type calcium-channel gene mutated in incomplete X-linkedcongenital stationary night blindness.Nature Genetics 19,260\u2013263.","DOI":"10.1038\/940"},{"key":"S095252380623102X_ref029","unstructured":"Haeseleer, F. , Imanishi, Y. , Maeda, T. , Possin, D.E. , Maeda, A. , Lee, A. , Rieke, F. , & Palczewski, K. (2004).Essential role of Ca2+-binding protein 4, a Cav1.4channel regulator, in photoreceptor synaptic function.Nature Neuroscience 7,1079\u20131087."},{"key":"S095252380623102X_ref064","doi-asserted-by":"publisher","DOI":"10.1023\/A:1001891904176"},{"key":"S095252380623102X_ref080","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.5.621"},{"key":"S095252380623102X_ref057","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1355-1_34"},{"key":"S095252380623102X_ref044","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi336"},{"key":"S095252380623102X_ref023","unstructured":"Greenstein, V.C. , Hood, D.C. , Siegel, I.M. , & Carr, R.E. (1988).A possible use of rod\u2013cone interaction in congenitalstationary nightblindness.Clinical Vision Sciences 3,69\u201374."},{"key":"S095252380623102X_ref066","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-004-5734-1"},{"key":"S095252380623102X_ref067","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225142"},{"key":"S095252380623102X_ref039","unstructured":"Kofuji, P. , Ceelen, P. , Zahs, K.R. , Surbeck, L.W. , Lester, H.A. , & Newman, E.A. (2000).Genetic inactivation of an inwardly rectifying potassium channel(Kir4.1 subunit) in mice: Phenotypic impact in retina.Journal of Neuroscience 20,5733\u20135740."},{"key":"S095252380623102X_ref050","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00719.x"},{"key":"S095252380623102X_ref035","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800009275"},{"key":"S095252380623102X_ref086","unstructured":"Zeitz, C. , Minotti, R. , Feil, S. , M\u00e1ty\u00e1s, G. , Cremers, F.P.M. , Hoyng, C.B. , & Berger, W. (2005).Novel mutations in CACNA1F and NYX in Dutchfamilies with X-linked congenital stationary night blindness.Molecular Vision 11,179\u2013183."},{"key":"S095252380623102X_ref065","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90438-3"},{"key":"S095252380623102X_ref061","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(93)90038-H"},{"key":"S095252380623102X_ref081","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.08.021"},{"key":"S095252380623102X_ref032","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501907102"}],"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S095252380623102X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:03:37Z","timestamp":1735848217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S095252380623102X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S095252380623102X"],"URL":"https:\/\/doi.org\/10.1017\/s095252380623102x","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006 Cambridge University Press","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}