{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:40:56Z","timestamp":1778895656072,"version":"3.51.4"},"reference-count":36,"publisher":"Maximum Academic Press","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"unspecified","delay-in-days":130,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nucleoredoxin-like gene <jats:italic>Nxnl1<\/jats:italic> (<jats:italic>Txnl6<\/jats:italic>) and\n                    its paralogue <jats:italic>Nxnl2<\/jats:italic> encode the rod-derived cone viability\n                    factors (RdCVF and RdCVF2), which increase the resistance to photooxidative\n                    damage and have therapeutic potential for the survival of cones in retinitis\n                    pigmentosa. In this study, the transcription of <jats:italic>Nxnl<\/jats:italic> genes was\n                    investigated as a function of the day\/night cycle in rats. The transcript levels\n                    of <jats:italic>Nxnl1<\/jats:italic> and <jats:italic>Nxnl2<\/jats:italic> were seen to display daily\n                    rhythms with steadily increasing values during the light phase and peak\n                    expression around dark onset in preparations of whole retina, photoreceptor\n                    cells and\u2014but only in regard to <jats:italic>Nxnl1<\/jats:italic>\u2014in\n                    photoreceptor-related pinealocytes. The cycling of <jats:italic>Nxnl1<\/jats:italic> but\n                    not that of <jats:italic>Nxnl2<\/jats:italic> persisted in constant darkness in the retina.\n                    This suggests that daily regulation of <jats:italic>Nxnl1<\/jats:italic> is driven by a\n                    circadian clock, whereas that of <jats:italic>Nxnl2<\/jats:italic> is promoted by\n                    environmental light. The present data indicate clock- and light-dependent\n                    regulations of nucleoredoxin-like genes that may be part of a protective shield\n                    against photooxidative damage.<\/jats:p>","DOI":"10.1017\/s0952523814000352","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T07:25:42Z","timestamp":1437031542000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Transcriptional regulation of nucleoredoxin-like genes takes place on\n                    a daily basis in the retina and pineal gland of rats"],"prefix":"10.48130","volume":"32","author":[{"given":"TANJA","family":"WOLLOSCHECK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEFANIE","family":"KUNST","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEBRA 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