{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:18:01Z","timestamp":1774973881550,"version":"3.50.1"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:p>We examined cytochrome oxidase (CO) activity in \nstriate cortex of four macaque monkeys after monocular \nenucleation at ages 1, 1, 5, and 12 weeks. These animal \nexperiments were performed to guide our interpretation \nof CO patterns in occipital lobe specimens obtained from \ntwo children who died several years after monocular enucleation \nduring infancy for tumor. In the macaques, the ocular dominance \ncolumns were labelled by injecting [<jats:sup>3<\/jats:sup>H]proline \ninto the remaining eye. After enucleation at age 1 week, \nocular dominance columns were eliminated in layer IVc\u03b2, \nresulting in a uniform pattern of autoradiographic label \nand CO staining. However, columns could still be seen in \nwet, unstained sections and with the Liesegang silver stain. \nAutoradiographs through layers IVc\u03b1 and IVa showed \nresidual, shrunken columns belonging to the missing eye, \nindicating that enucleation has less drastic effects in \nthese layers. In the two human cases, enucleation at age \n1 week also resulted in uniform CO staining in layer IVc. \nIn the macaque after enucleation at age 5 weeks, ocular \ndominance columns belonging to the missing eye were severely \nnarrowed, but still occupied 20% of layer IVc\u03b2. CO \nrevealed wide, dark columns alternating with thin, pale \ncolumns in layer IVc\u03b2. The CO pattern and the columns \nlabelled by autoradiography matched perfectly. After enucleation \nat age 12 weeks, only mild shrinkage of ocular dominance \ncolumns occurred. Enucleation at ages 1, 5, and 12 weeks \ndid not alter the pattern of thin-pale\u2013thick-pale \nstripes in V2. The main findings from this study were that \n(1) CO histochemistry accurately labels the boundaries \nof columns in layer IVc\u03b2 of macaque striate cortex \nafter early monocular enucleation, making it a suitable \ntechnique for defining the critical period for plasticity \nof ocular dominance columns in human striate cortex; (2) \nenucleation causes more severe shrinkage of ocular dominance \ncolumns than eyelid suture; (3) early monocular enucleation \nobliterates ocular dominance columns in layer IVc\u03b2, \nbut their pattern remains visible in wet sections and with \nthe Liesegang stain; and (4) enucleation does not affect \nCO staining in V2.<\/jats:p>","DOI":"10.1017\/s0952523898152124","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:08Z","timestamp":1027777148000},"page":"289-303","source":"Crossref","is-referenced-by-count":42,"title":["Effect of early monocular enucleation upon ocular dominance \ncolumns and cytochrome oxidase activity in monkey and human \nvisual cortex"],"prefix":"10.48130","volume":"15","author":[{"given":"JONATHAN C.","family":"HORTON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVINA R.","family":"HOCKING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[1998,2,1]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523898152124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:58:44Z","timestamp":1735847924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523898152124\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["S0952523898152124"],"URL":"https:\/\/doi.org\/10.1017\/s0952523898152124","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}