{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:25:26Z","timestamp":1790141126205,"version":"4.0.1"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>Previous physiological studies have shown that \nserotonin (5-HT) reciprocally modulates ON and OFF channels \nin the mammalian retina. This study was undertaken to determine \nif the serotoninergic system is exclusively associated \nwith the rod pathway. We tested drugs specific to 5-HT<jats:sub>3<\/jats:sub> \nreceptor, a serotonin-gated ion channel, in both dark- \nand light-adapted retina. Consistent with previous studies, \nwe demonstrated that 5-HT<jats:sub>3<\/jats:sub> receptors modulate \nthe light-evoked responses of ganglion cells in the dark-adapted \nstate. Moreover, we have extended these prior studies and \nshown that activation of the 5-HT<jats:sub>3<\/jats:sub> receptor \nis capable of completely blocking the light-evoked response \nof OFF-center cells whereas inactivation of the 5-HT<jats:sub>3<\/jats:sub> \nreceptor is capable of completely blocking the light-evoked \nresponses of ON-center cells. In contrast, in light-adapted \nretinae, serotonin agents failed to have any effect on \nretinal processing. These data suggest that the serotoninergic \nsystem in retina is (1) specifically associated with rod-related \npathways; and (2) exerts a powerful modulatory force over \ninformation transfer in the retina. Together these observations \nsuggests that serotonin plays an important physiological \nrole in modulating retinal processing.<\/jats:p>","DOI":"10.1017\/s0952523898155116","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:16Z","timestamp":1027777156000},"page":"891-902","source":"Crossref","is-referenced-by-count":13,"title":["Serotonin receptors modulate rod signals: A neuropharmacological \ncomparison of light- and dark-adapted retinas"],"prefix":"10.48130","volume":"15","author":[{"given":"XIAO TAO","family":"JIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM J.","family":"BRUNKEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27968","published-online":{"date-parts":[[1998,5,1]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523898155116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:59:06Z","timestamp":1735847946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523898155116\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0952523898155116"],"URL":"https:\/\/doi.org\/10.1017\/s0952523898155116","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}