{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:50:19Z","timestamp":1759564219961,"version":"3.32.0"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>GABAergic responses of acutely dissociated rat \nretinal neurons, including both bipolar cells (BCs) and \nother, morphologically round cells (RCs), were assayed \nwith the fluorescent (FL), voltage-sensitive probe oxonol \nDiBaC<jats:sub>4<\/jats:sub>(5). Using intensified video microscopy \nand simultaneous recording, GABA responses were identified \nin one-third of cells in a typical microscope field; of \nthese 85% hyperpolarized (0.05\u20130.3 log unit FL decreases) \nwhile the remainder depolarized (0.05\u20130.2 log unit \nFL increases). GABA-sensitive cells were also TACA-sensitive \n(<jats:italic>trans<\/jats:italic>-4-Aminocrotonic acid), and these ligands \nappeared interchangeable in ability to evoke responses. \nIn RCs, an asymmetric co-responsive pattern was observed \nbetween GABA- and muscimol-evoked events. Muscimol-sensitive \nRCs responded well to GABA, but not all GABA-sensitive \nRCs responded to muscimol. In GABA-sensitive BCs, muscimol \nresponses were typically weak or absent. Few BCs or RCs \nresponded to CACA (<jats:italic>cis<\/jats:italic>-4-Aminocrotonic acid). \nBicuculline-resistant GABA responses occurred in \u223c80% \nof GABA-responsive RCs and BCs. Both bicuculline-sensitive \n(GABA<jats:sub>A<\/jats:sub>-like) and bicuculline-insensitive (GABA<jats:sub>C<\/jats:sub>-like) \nresponses were resistant to picrotoxin. Although a small \nminority of GABA-sensitive cells hyperpolarized in response \nto R(+)baclofen, bicuculline-insensitive responses were \nnot antagonized by 2-hydroxysaclofen, and were abolished \nin low [Cl<jats:sup>\u2212<\/jats:sup>]<jats:sub>o<\/jats:sub>. Results \nsuggested (1) that bicuculline-insensitive, Cl<jats:sup>\u2212<\/jats:sup>-dependent, \nGABA<jats:sub>C<\/jats:sub>-like responses were broadly distributed \nand predominant among dissociated rat retinal neurons; \n(2) that muscimol was a particularly weak agonist for rat \nretinal BCs; and (3) that oxonol was a sensitive probe \nfor retinal GABA responses.<\/jats:p>","DOI":"10.1017\/s0952523899161133","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:08Z","timestamp":1027777148000},"page":"179-190","source":"Crossref","is-referenced-by-count":9,"title":["Distribution of GABA<sub>C<\/sub>-like responses among acutely \ndissociated rat retinal neurons"],"prefix":"10.48130","volume":"16","author":[{"given":"RALPH","family":"NELSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNE E.","family":"SCHAFFNER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONG-XIN","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARC K.","family":"WALTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[1999,1,1]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523899161133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:59:37Z","timestamp":1735847977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523899161133\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S0952523899161133"],"URL":"https:\/\/doi.org\/10.1017\/s0952523899161133","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"type":"print","value":"0952-5238"},{"type":"electronic","value":"1469-8714"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}