{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:52:25Z","timestamp":1790747545382,"version":"4.1.0"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"4","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>We studied the light-evoked responses of AII amacrine \ncells in the rabbit retina under dark- and light-adapted \nconditions. In contrast to the results of previous studies, \nwe found that AII cells display robust responses to light \nover a 6\u20137 log unit intensity range, well beyond \nthe operating range of rod photoreceptors. Under dark adaptation, \nAII cells showed an ON-center\/OFF-surround receptive-field \norganization. The intensity\u2013response profile of the \ncenter-mediated response component followed a dual-limbed \nsigmoidal function indicating a transition from rod to \ncone mediation as stimulus intensities were increased. \nFollowing light adaptation, the receptive-field organization \nof AII cells changed dramatically. Light-adapted AII cells \nshowed both ON- and OFF-responses to stimulation of the \ncenter receptive field, but we found no evidence for an \nantagonistic surround. Interestingly, the OFF-center response \nappeared first following rapid light adaptation and was \nthen replaced gradually over a 1\u20134 min period by \nthe emerging ON-center response component. Application \nof the metabotropic glutamate receptor agonist APB, the \nionotropic glutamate blocker CNQX, 8-bromo-cGMP, and the \nnitric oxide donor SNAP all showed differential effects \non the various center-mediated responses displayed by dark- \nand light-adapted AII cells. Taken together, these pharmacological \nresults indicated that different synaptic circuits are \nresponsible for the generation of the different AII cell \nresponses. Specifically, the rod-driven ON-center responses \nare apparently derived from rod bipolar cell synaptic inputs, \nwhereas the cone-driven ON-center responses arise from \nsignals crossing the gap junctions between AII cells and \nON-center cone bipolar cells. Additionally, the OFF-center \nresponse of light-adapted AII cells reflects direct synaptic \ninputs from OFF-center cone bipolar cells to AII dendritic \nprocesses in the distal inner plexiform layer.<\/jats:p>","DOI":"10.1017\/s0952523899164058","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:08Z","timestamp":1027777148000},"page":"653-665","source":"Crossref","is-referenced-by-count":97,"title":["Comparison of the responses of AII amacrine cells in the \ndark- and light-adapted rabbit retina"],"prefix":"10.48130","volume":"16","author":[{"given":"DAIYAN","family":"XIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEWART A.","family":"BLOOMFIELD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27968","published-online":{"date-parts":[[1999,7,1]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523899164058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:00:02Z","timestamp":1735848002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523899164058\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S0952523899164058"],"URL":"https:\/\/doi.org\/10.1017\/s0952523899164058","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}