{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:03:47Z","timestamp":1777640627430,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycological Research"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1017\/s095375620300769x","type":"journal-article","created":{"date-parts":[[2003,8,7]],"date-time":"2003-08-07T15:44:41Z","timestamp":1060271081000},"page":"717-726","source":"Crossref","is-referenced-by-count":13,"title":["Isolation of Penicillium nalgiovense strains impaired in penicillin production by disruption of the pcbAB gene and application as starters on cured meat products"],"prefix":"10.1016","volume":"107","author":[{"given":"Federico","family":"Laich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1017\/S095375620300769X_bib1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1472-765X.1994.tb00988.x","article-title":"Penicillin production by Penicillium nalgiovense","volume":"19","author":"Andersen","year":"1994","journal-title":"Letters in Applied Microbiology"},{"key":"10.1017\/S095375620300769X_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0378-1119(90)90274-U","article-title":"Molecular cloning and deletion of the gene encoding aspergillopepsin A from Aspergillus awamori","volume":"86","author":"Berka","year":"1990","journal-title":"Gene"},{"key":"10.1017\/S095375620300769X_bib3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4315\/0362-028X-57.10.928","article-title":"Molds as protective cultures for raw dry sausages. J","volume":"57","author":"Berwall","year":"1994","journal-title":"Food Prot"},{"key":"10.1017\/S095375620300769X_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00277348","article-title":"Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted disruption of the acvA gene","volume":"242","author":"Brakhage","year":"1994","journal-title":"Molecular and General Genetics"},{"key":"10.1017\/S095375620300769X_bib5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1128\/JB.181.4.1181-1188.1999","article-title":"Gene targeting in Penicillum chrysogenum: disruption of the lys2 gene leads to penicillin overproduction","volume":"181","author":"Casqueiro","year":"1999","journal-title":"Journal of Bacteriology"},{"key":"10.1017\/S095375620300769X_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2672.1996.tb03228.x","article-title":"Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture","volume":"80","author":"Cochet","year":"1996","journal-title":"Journal of Applied Bacteriology"},{"key":"10.1017\/S095375620300769X_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00798750","article-title":"Transformation of Neuro-spora crassa with circular and linear DNA and analysis of the fate of the transforming DNA","volume":"10","author":"Dhawale","year":"1985","journal-title":"Current Genetics"},{"key":"10.1017\/S095375620300769X_bib8","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1128\/AEM.60.9.3401-3404.1994","article-title":"Antagonistic activity of the food-related filamentous fungus Penicillium nalgiovense by the production of penicillin","volume":"60","author":"F\u00e4rber","year":"1994","journal-title":"Applied of Environmental Microbiology"},{"key":"10.1017\/S095375620300769X_bib9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF00172491","article-title":"Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence","volume":"44","author":"Fierro","year":"1996","journal-title":"Applied Microbiology and Biotechnology"},{"key":"10.1017\/S095375620300769X_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0740-0020(95)80111-1","article-title":"Microbial succession and identification of Micrococcaceae in dried beef cecina, an intermediate moisture meat products","volume":"12","author":"Garc\u00eda","year":"1995","journal-title":"Food Microbiology"},{"key":"10.1017\/S095375620300769X_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00447050","article-title":"Transformation of Penicillium nalgiovense with the amdS gene of Aspergillus nidulans","volume":"15","author":"Geisen","year":"1989","journal-title":"Current Genetics"},{"key":"10.1017\/S095375620300769X_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0740-0020(86)80021-1","article-title":"The role of moulds in the ripening process of salami","volume":"3","author":"Grazia","year":"1986","journal-title":"Food Microbiology"},{"key":"10.1017\/S095375620300769X_bib13","first-page":"669","article-title":"Antibiotics in mould-cured salami","volume":"52","author":"Horwitz","year":"1977","journal-title":"South African Medical Journal"},{"key":"10.1017\/S095375620300769X_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF00327023","article-title":"Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremonium","volume":"18","author":"Hoskins","year":"1990","journal-title":"Current Genetics"},{"key":"10.1017\/S095375620300769X_bib15","first-page":"289","article-title":"Enzymatic activities and antimicrobial effects of Aspergillus and Penicillium strains isolated from Spanish dry cured hams: quantitative and qualitative aspects","volume":"5","author":"Huerta","year":"1987","journal-title":"Microbiology of Alimentation and Nutrition"},{"key":"10.1017\/S095375620300769X_bib16","first-page":"181","article-title":"Alimentary anaphylactic shock: implication of penicillin residues","volume":"26","author":"Kanny","year":"1994","journal-title":"Allergemeire de Immunologie (Paris)"},{"key":"10.1017\/S095375620300769X_bib17","unstructured":"Lacey, J. & Magan, N. (1991) Fungi in cereal grains: their occurrence and water and temperature relationships. In Cereal Grain: mycotoxins, fungi and quality in drying and storage (J. Chelkowski, ed.): 77\u2013118. Elsevier, Amsterdam."},{"key":"10.1017\/S095375620300769X_bib18","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1128\/AEM.65.3.1236-1240.1999","article-title":"Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages","volume":"65","author":"Laich","year":"1999","journal-title":"Applied and Environmental Microbiology"},{"key":"10.1017\/S095375620300769X_bib19","unstructured":"Leistner, L. & Pitt, J. I. (1974) Miscellaneous Penicillium toxins. In Mycotoxins in Human and Animal Health (J. V. Rodricks, C. W. Hesseltine & M. A. Mehlmann, eds): 639\u2013658. Park Forest South, IL."},{"key":"10.1017\/S095375620300769X_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1398-9995.1981.tb01858.x","article-title":"Challenge of penicillin-allergic volunteers with penicillin-contaminated meat","volume":"36","author":"Lindemayr","year":"1981","journal-title":"Allergy"},{"key":"10.1017\/S095375620300769X_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1439-0450.1972.tb00406.x","article-title":"Untersuchungen Zur Selektion eines technologish geeigneten and toxikologisch unbodenklichen Schimmelpilz-Stammes fur die Rohwurst-Herstellung","volume":"19","author":"Mintzlaff","year":"1972","journal-title":"Zentralblatt f\u00fcr Vetenerische und Medizin B"},{"key":"10.1017\/S095375620300769X_bib22","series-title":"Fermented Meats","first-page":"194","article-title":"Fungal toxins in raw and fermented meats","author":"Pestka","year":"1995"},{"key":"10.1017\/S095375620300769X_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4315\/0362-028X-51.5.419","article-title":"Proposed theoretical literature values at various temperatures for selected solutions to be used as reference sources in the range of microbial growth","volume":"51","author":"Resnik","year":"1988","journal-title":"Journal of Food Protect"},{"key":"10.1017\/S095375620300769X_bib24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0076-6879(83)01015-0","article-title":"One-step gene disruption in yeast","volume":"101","author":"Rothstein","year":"1983","journal-title":"Methods of Enzymology"},{"key":"10.1017\/S095375620300769X_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/fgbi.1999.1162","article-title":"Deletion of the trichodiene synthase gene of Fusarium venenatum: two systems for repeated gene deletions","volume":"28","author":"Royer","year":"1999","journal-title":"Fungal Genetics and Biology"},{"key":"10.1017\/S095375620300769X_bib26","series-title":"Molecular Cloning: a laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1017\/S095375620300769X_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1128\/AEM.67.2.561-568.2001","article-title":"Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon","volume":"67","author":"Shoemaker","year":"2001","journal-title":"Applied and Environmental Microbiology"},{"key":"10.1017\/S095375620300769X_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00279995","article-title":"Disruption of a Magnaporte grisea cutinase gene","volume":"232","author":"Sweigard","year":"1992","journal-title":"Molecular and General Genetics"},{"key":"10.1017\/S095375620300769X_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00351851","article-title":"Targeted integration into the Acremonium chrysogenum genome: disruption of the pcbC gene","volume":"24","author":"Walz","year":"1993","journal-title":"Current Genetics"},{"key":"10.1017\/S095375620300769X_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S0953756298006698","article-title":"Transformation of sapstaining fungi with hygromycin B resistance plasmids pAN7-1 and pCB1004","volume":"103","author":"Wang","year":"1999","journal-title":"Mycological Research"},{"key":"10.1017\/S095375620300769X_bib31","series-title":"Fungal Biotechnology","first-page":"3","article-title":"Traditional fermented food","author":"Wolf","year":"1997"}],"container-title":["Mycological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953756208612502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0953756208612502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T13:18:55Z","timestamp":1704892735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0953756208612502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0953756208612502"],"URL":"https:\/\/doi.org\/10.1017\/s095375620300769x","relation":{},"ISSN":["0953-7562"],"issn-type":[{"value":"0953-7562","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}