{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:01:36Z","timestamp":1783764096098,"version":"3.55.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr. Res. Rev."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Chronic pelvic pain (CPP) can be identified as a chronic nociceptive, inflammatory and neuropathic pain characterised by spontaneous pain and an exaggerated response to painful and\/or innocuous stimuli. This pain condition is extremely debilitating and usually difficult to treat. Currently, the main approaches to treatment include counselling supported by reassuring ultrasound scanning or psychotherapy, attempting to provide reassurance using laparoscopy to exclude serious pelvic pathology, hormonal therapy and neuroablative treatment to interrupt nerve pathways. Dietary supplementation has been suggested as a means to treat chronic medical illnesses that are poorly responsive to prescription drugs or in which therapeutic options are limited, costly or carry a high side-effect profile. A comprehensive search of the PubMed database was performed using the search terms \u2018chronic pelvic pain\u2019, \u2018oxidative stress\u2019, \u2018antioxidants\u2019 and \u2018dietary therapy\u2019. The systematic review focuses on both randomised and non-randomised controlled trials from 2005 onwards, in which CPP was the end point. Given the complexity and not well-understood aetiology of CPP, its treatment is often unsatisfactory and limited to partial symptom relief. Dietary therapy with antioxidants improves function of the immune system and in fighting free radical damage. Agents with antioxidant activity are able to improve CPP without undesired effects and any important metabolic changes associated with hormonal suppression therapy. In conclusion, dietary therapy with antioxidants could be considered as a new effective strategy in the long term for CPP, and may be better accepted by patients. Further randomised trials with larger series and long-term follow-up to confirm these observations are needed.<\/jats:p>","DOI":"10.1017\/s0954422410000272","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T04:57:17Z","timestamp":1287982637000},"page":"31-38","source":"Crossref","is-referenced-by-count":31,"title":["Dietary therapy: a new strategy for management of chronic pelvic pain"],"prefix":"10.1017","volume":"24","author":[{"given":"Francesco","family":"Sesti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Capozzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalgisa","family":"Pietropolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Collalti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Bollea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Piccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"S0954422410000272_ref8","doi-asserted-by":"publisher","DOI":"10.1300\/J070v15n03_04"},{"key":"S0954422410000272_ref64","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq044"},{"key":"S0954422410000272_ref61","first-page":"1181","article-title":"A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea","volume":"108","author":"Ziaei","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"S0954422410000272_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"S0954422410000272_ref55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00495.x"},{"key":"S0954422410000272_ref48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3376"},{"key":"S0954422410000272_ref62","first-page":"31","article-title":"Brief communication: the prevalence of high intake of vitamin E from the use of supplements among US adults","volume":"29","author":"Ford","year":"2005","journal-title":"Ann Inter Med"},{"key":"S0954422410000272_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04216-4"},{"key":"S0954422410000272_ref40","first-page":"887","article-title":"Increased nitric oxide in peritoneal fluid from women with idiopathic infertility and endometriosis","volume":"46","author":"Dong","year":"2001","journal-title":"J Reprod Med"},{"key":"S0954422410000272_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.053"},{"key":"S0954422410000272_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"S0954422410000272_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00266-8"},{"key":"S0954422410000272_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2003.11.001"},{"key":"S0954422410000272_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.035"},{"key":"S0954422410000272_ref49","first-page":"211","article-title":"The mechanism of Polydatin in shock treatment","volume":"29","author":"Zhao","year":"2003","journal-title":"Clin Hemorheol Microcirc"},{"key":"S0954422410000272_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2009.06.017"},{"key":"S0954422410000272_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70681-6"},{"key":"S0954422410000272_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2006.01.004"},{"key":"S0954422410000272_ref51","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh395"},{"key":"S0954422410000272_ref16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.5.G670"},{"key":"S0954422410000272_ref15","first-page":"632","article-title":"J.J. 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