{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:02:28Z","timestamp":1791356548802,"version":"4.3.1"},"reference-count":168,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Nutr. Res. Rev."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Nutrition plays an important role in osteoporosis prevention and treatment. Substantial progress in both laboratory analyses and clinical use of biochemical markers has modified the strategy of anti-osteoporotic drug development. The present review examines the use of biochemical markers in clinical research aimed at characterising the influence of foods or nutrients on bone metabolism. The two types of markers are: (i) specific hormonal factors related to bone; and (ii) bone turnover markers (BTM) that reflect bone cell metabolism. Of the former, vitamin D metabolites, parathyroid hormone, and insulin-like growth factor-I indicate responses to variations in the supply of bone-related nutrients, such as vitamin D, Ca, inorganic phosphate and protein. Thus modification in bone remodelling, the key process upon which both pharmaceutical agents and nutrients exert their anti-catabolic or anabolic actions, is revealed. Circulating BTM reflect either osteoclastic resorption or osteoblastic formation. Intervention with pharmacological agents showed that early changes in BTM predicted bone loss and subsequent osteoporotic fracture risk. New trials have documented the influence of nutrition on bone-tropic hormonal factors and BTM in adults, including situations of body-weight change, such as anorexia nervosa, and weight loss by obese subjects. In osteoporosis-prevention studies involving dietary manipulation, randomised cross-over trials are best suited to evaluate influences on bone metabolism, and insight into effects on bone metabolism may be gained within a relatively short time when biochemical markers are monitored.<\/jats:p>","DOI":"10.1017\/s0954422414000183","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T18:54:25Z","timestamp":1415991265000},"page":"252-267","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":46,"title":["Biochemical markers for assessment of calcium economy and bone metabolism: application in clinical trials from pharmaceutical agents to nutritional products"],"prefix":"10.1017","volume":"27","author":[{"given":"Jean-Philippe","family":"Bonjour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kohrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Levasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Whiting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Kraenzlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,11,14]]},"reference":[{"key":"S0954422414000183_ref64","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.8.1272"},{"key":"S0954422414000183_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50021-2"},{"key":"S0954422414000183_ref107","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170020"},{"key":"S0954422414000183_ref138","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8574"},{"key":"S0954422414000183_ref69","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/clinchem\/47.3.597","article-title":"Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption","volume":"47","author":"Halleen","year":"2001","journal-title":"Clin Chem"},{"key":"S0954422414000183_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(01)00261-6"},{"key":"S0954422414000183_ref20","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:1:4:395"},{"key":"S0954422414000183_ref134","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/ajcn\/86.1.92","article-title":"Treatment of anorexia nervosa is associated with increases in bone mineral density, and recovery is a biphasic process involving both nutrition and return of menses","volume":"86","author":"Dominguez","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"S0954422414000183_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050161"},{"key":"S0954422414000183_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.10.010"},{"key":"S0954422414000183_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9138-0"},{"key":"S0954422414000183_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00271-4"},{"key":"S0954422414000183_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.04.002"},{"key":"S0954422414000183_ref160","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.506449"},{"key":"S0954422414000183_ref162","first-page":"1201","article-title":"What is evidence-based medicine and why should it be practiced?","volume":"46","author":"Montori","year":"2001","journal-title":"Respir Care"},{"key":"S0954422414000183_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.08.010"},{"key":"S0954422414000183_ref47","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"S0954422414000183_ref77","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070002"},{"key":"S0954422414000183_ref111","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060624"},{"key":"S0954422414000183_ref89","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50038-8"},{"key":"S0954422414000183_ref48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"S0954422414000183_ref164","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-27"},{"key":"S0954422414000183_ref10","volume-title":"Assessment of Osteoporosis at the Primary Health Care Level. Report of a WHO Scientific Group","year":"2007"},{"key":"S0954422414000183_ref139","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.9.7633"},{"key":"S0954422414000183_ref74","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111021"},{"key":"S0954422414000183_ref46","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2010.514366"},{"key":"S0954422414000183_ref63","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0431"},{"key":"S0954422414000183_ref56","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1959"},{"key":"S0954422414000183_ref124","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2008.00934.x"},{"key":"S0954422414000183_ref130","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.07.003"},{"key":"S0954422414000183_ref133","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011889"},{"key":"S0954422414000183_ref66","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1501-1"},{"key":"S0954422414000183_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0073-6"},{"key":"S0954422414000183_ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.12.020"},{"key":"S0954422414000183_ref140","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1700003"},{"key":"S0954422414000183_ref167","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.180"},{"key":"S0954422414000183_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.02.009"},{"key":"S0954422414000183_ref72","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/clinchem\/47.4.694","article-title":"Evaluation of a fully automated serum assay for C-terminal cross-linking teleopeptide of type I collagen in osteoporosis","volume":"47","author":"Garnero","year":"2001","journal-title":"Clin Chem"},{"key":"S0954422414000183_ref116","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070111"},{"key":"S0954422414000183_ref38","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020275"},{"key":"S0954422414000183_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00404.x"},{"key":"S0954422414000183_ref112","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.108"},{"key":"S0954422414000183_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.04.002"},{"key":"S0954422414000183_ref80","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070007"},{"key":"S0954422414000183_ref156","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9232-z"},{"key":"S0954422414000183_ref128","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0003-y"},{"key":"S0954422414000183_ref129","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00494-7"},{"key":"S0954422414000183_ref127","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509371743"},{"key":"S0954422414000183_ref168","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-32"},{"key":"S0954422414000183_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00405.x"},{"key":"S0954422414000183_ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1052-5"},{"key":"S0954422414000183_ref110","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050929"},{"key":"S0954422414000183_ref58","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-10-199805150-00002"},{"key":"S0954422414000183_ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-010-0142-7"},{"key":"S0954422414000183_ref50","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2601"},{"key":"S0954422414000183_ref166","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10719776"},{"key":"S0954422414000183_ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.10.004"},{"key":"S0954422414000183_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05463-X"},{"key":"S0954422414000183_ref142","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8637"},{"key":"S0954422414000183_ref121","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.153692"},{"key":"S0954422414000183_ref88","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040512"},{"key":"S0954422414000183_ref68","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.4.683"},{"key":"S0954422414000183_ref161","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080301"},{"key":"S0954422414000183_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50034-0"},{"key":"S0954422414000183_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1722-9"},{"key":"S0954422414000183_ref148","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ajcn\/73.2.347","article-title":"Moderate energy restriction increases bone resorption in obese postmenopausal women","volume":"73","author":"Ricci","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"S0954422414000183_ref122","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(99)00302-8"},{"key":"S0954422414000183_ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070005"},{"key":"S0954422414000183_ref82","first-page":"1904","article-title":"The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation","volume":"82","author":"Rosen","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref60","first-page":"111","volume-title":"Nutritional Aspects of Bone Health","author":"Bonjour","year":"2003"},{"key":"S0954422414000183_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1561-x"},{"key":"S0954422414000183_ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3060"},{"key":"S0954422414000183_ref37","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1758"},{"key":"S0954422414000183_ref22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pu.17.050196.002455"},{"key":"S0954422414000183_ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000351481"},{"key":"S0954422414000183_ref39","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7327"},{"key":"S0954422414000183_ref51","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2218"},{"key":"S0954422414000183_ref53","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1404"},{"key":"S0954422414000183_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-003-1103-1"},{"key":"S0954422414000183_ref79","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.9.1614"},{"key":"S0954422414000183_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2013.01.005"},{"key":"S0954422414000183_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2074-y"},{"key":"S0954422414000183_ref36","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258"},{"key":"S0954422414000183_ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0009-8"},{"key":"S0954422414000183_ref73","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110307"},{"key":"S0954422414000183_ref34","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050609"},{"key":"S0954422414000183_ref57","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.150631"},{"key":"S0954422414000183_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00307.x"},{"key":"S0954422414000183_ref59","first-page":"80","article-title":"Nutritional regulation of the insulin-like growth factors","volume":"15","author":"Thissen","year":"1994","journal-title":"Endocr Rev"},{"key":"S0954422414000183_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0133-8"},{"key":"S0954422414000183_ref70","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-442"},{"key":"S0954422414000183_ref49","first-page":"42","article-title":"Defining vitamin D status by secondary hyperparathyroidism in the U.S. population","volume":"35","author":"Ginde","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"S0954422414000183_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.10.001"},{"key":"S0954422414000183_ref96","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00301-X"},{"key":"S0954422414000183_ref45","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213491236"},{"key":"S0954422414000183_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000221637.90495.66"},{"key":"S0954422414000183_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50031-5"},{"key":"S0954422414000183_ref86","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301244"},{"key":"S0954422414000183_ref147","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.1.141"},{"key":"S0954422414000183_ref9","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.602"},{"key":"S0954422414000183_ref61","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0036"},{"key":"S0954422414000183_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-011-0074-z"},{"key":"S0954422414000183_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.86"},{"key":"S0954422414000183_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-209"},{"key":"S0954422414000183_ref19","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/jn\/138.9.1591","article-title":"Nutrients, endpoints, and the problem of proof","volume":"138","author":"Heaney","year":"2008","journal-title":"J Nutr"},{"key":"S0954422414000183_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61342-7"},{"key":"S0954422414000183_ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0286-8"},{"key":"S0954422414000183_ref7","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2012.32.2.105"},{"key":"S0954422414000183_ref52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.18.2257"},{"key":"S0954422414000183_ref35","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.10.1108"},{"key":"S0954422414000183_ref75","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.11.74"},{"key":"S0954422414000183_ref85","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7029.482"},{"key":"S0954422414000183_ref100","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01124-X"},{"key":"S0954422414000183_ref143","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040410"},{"key":"S0954422414000183_ref126","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1274"},{"key":"S0954422414000183_ref83","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.8.1526"},{"key":"S0954422414000183_ref113","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1712"},{"key":"S0954422414000183_ref98","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1091"},{"key":"S0954422414000183_ref99","first-page":"2363","article-title":"Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study","volume":"84","author":"Ravn","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref131","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-10-200011210-00011"},{"key":"S0954422414000183_ref104","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050814"},{"key":"S0954422414000183_ref135","first-page":"4489","article-title":"The effects of anorexia nervosa on bone metabolism in female adolescents","volume":"84","author":"Soyka","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref153","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/jn\/138.6.1096","article-title":"A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adults","volume":"138","author":"Thorpe","year":"2008","journal-title":"J Nutr"},{"key":"S0954422414000183_ref144","doi-asserted-by":"publisher","DOI":"10.1159\/000323771"},{"key":"S0954422414000183_ref146","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.263"},{"key":"S0954422414000183_ref97","first-page":"1904","article-title":"The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation","volume":"82","author":"Rosen","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref152","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/jn\/134.3.568","article-title":"A high dairy protein, high-calcium diet minimizes bone turnover in overweight adults during weight loss","volume":"134","author":"Bowen","year":"2004","journal-title":"J Nutr"},{"key":"S0954422414000183_ref108","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.6.1051"},{"key":"S0954422414000183_ref165","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0904133"},{"key":"S0954422414000183_ref137","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00879.x"},{"key":"S0954422414000183_ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9571-z"},{"key":"S0954422414000183_ref132","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2304"},{"key":"S0954422414000183_ref101","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200017040-00007"},{"key":"S0954422414000183_ref159","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012370544-0.50033-1"},{"key":"S0954422414000183_ref141","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200101000-00004"},{"key":"S0954422414000183_ref93","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-005-0018-6"},{"key":"S0954422414000183_ref102","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8415"},{"key":"S0954422414000183_ref158","first-page":"1598","volume-title":"Osteoporosis","author":"Heaney","year":"2008"},{"key":"S0954422414000183_ref118","unstructured":"Swiss Association against Osteoporosis (2010) Osteoporosis: prevention, diagnosis and treatment. Recommendation 2010. http:\/\/www.SVGO.ch."},{"key":"S0954422414000183_ref87","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041207"},{"key":"S0954422414000183_ref95","first-page":"1693","article-title":"Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment","volume":"79","author":"Garnero","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref119","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/ajcn\/86.3.781","article-title":"Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: the Postmenopausal Health Study","volume":"86","author":"Manios","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"S0954422414000183_ref125","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(02)90356-1"},{"key":"S0954422414000183_ref105","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1770-7"},{"key":"S0954422414000183_ref145","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104655"},{"key":"S0954422414000183_ref150","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1329"},{"key":"S0954422414000183_ref151","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/ajcn\/85.4.972","article-title":"Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake","volume":"85","author":"Riedt","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"S0954422414000183_ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.06.004"},{"key":"S0954422414000183_ref157","doi-asserted-by":"publisher","DOI":"10.1159\/000341968"},{"key":"S0954422414000183_ref115","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X75096"},{"key":"S0954422414000183_ref106","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00236-9"},{"key":"S0954422414000183_ref120","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508937429"},{"key":"S0954422414000183_ref154","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.318"},{"key":"S0954422414000183_ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.07.003"},{"key":"S0954422414000183_ref136","first-page":"200","article-title":"The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa","volume":"85","author":"Hotta","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"S0954422414000183_ref117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01911.x"},{"key":"S0954422414000183_ref163","volume-title":"Basic and Clinical Biostatistics","author":"Dawson","year":"2001"},{"key":"S0954422414000183_ref123","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200512010-00012"},{"key":"S0954422414000183_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50032-7"},{"key":"S0954422414000183_ref78","first-page":"50","article-title":"Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women","volume":"4","author":"Garnero","year":"2004","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"S0954422414000183_ref11","first-page":"198","volume-title":"Primer of the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Harvey","year":"2008"},{"key":"S0954422414000183_ref103","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.1.6267"},{"key":"S0954422414000183_ref84","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050009"},{"key":"S0954422414000183_ref62","doi-asserted-by":"publisher","DOI":"10.1007\/BF03194340"},{"key":"S0954422414000183_ref149","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.6.1045"},{"key":"S0954422414000183_ref114","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050105"},{"key":"S0954422414000183_ref90","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200068"},{"key":"S0954422414000183_ref155","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1152\/jappl.1998.84.4.1305","article-title":"Aerobic exercise maintains regional bone mineral density during weight loss in postmenopausal women","volume":"84","author":"Ryan","year":"1998","journal-title":"J Appl Physiol"}],"container-title":["Nutrition Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954422414000183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T21:03:59Z","timestamp":1598475839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954422414000183\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,14]]},"references-count":168,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0954422414000183"],"URL":"https:\/\/doi.org\/10.1017\/s0954422414000183","relation":{},"ISSN":["0954-4224","1475-2700"],"issn-type":[{"value":"0954-4224","type":"print"},{"value":"1475-2700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,14]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2014\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}