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In the urogenital tract (UGT), resveratrol has also been tested clinically and experimentally as a therapeutic drug in several diseases; however, the translational efficacy of resveratrol, especially in UGT, is still a matter of debate. In the present review, we address the pre-clinical efficacy of resveratrol in UGT-related dysfunctions, focusing on lower urinary tract symptoms, non-cancerous prostatic disease (benign prostatic hyperplasia and prostatitis) and erectile dysfunction.<jats:italic>In vitro<\/jats:italic>studies indicate that resveratrol reduces inflammatory markers and oxidative stress, and improves endothelial function in UGT organs and cells isolated from humans and animals. Despite displaying low oral bioavailability,<jats:italic>in vivo<\/jats:italic>administration of resveratrol largely improves erectile dysfunction, benign prostatic hyperplasia, prostatitis and voiding impairments, as evidenced in different animal models. Resveratrol also acts as a microbiota modulator, which may explain some of its beneficial effects<jats:italic>in vivo<\/jats:italic>. In contrast to the large amount of pre-clinical data, there are insufficient clinical trials to establish resveratrol treatment efficacy in human UGT-related diseases. In summary, we provide an overview of the<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>efficacy of resveratrol in animal and human UGT dysfunctions, which may support future clinical trials.<\/jats:p>","DOI":"10.1017\/s0954422421000354","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T08:42:49Z","timestamp":1636965769000},"page":"86-97","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of resveratrol in male urogenital tract dysfunctions: an evaluation of pre-clinical 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