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This narrative review aims to summarise the chemistry, biology, serum indicators and clinical trials that have evaluated the impact of fortification and other relevant aspects of vitamin E, in addition to the prevalence of its deficiency, in children worldwide. Vitamin E intake in recommended amounts is essential for this nutrient to perform its functions in the body. Serum \u03b1-tocopherol is the most widely used biochemical indicator to assess the prevalence of VED. VED has been associated with symptoms secondary to fat malabsorption and may lead to peripheral neuropathy and increased erythrocyte haemolysis. Reduced concentrations of \u03b1-tocopherol may be caused by the combination of diets with low amounts of vitamin E and inadequate consumption of fats, proteins and calories. The lowest prevalence of VED was found in Asia and the highest in North America and Brazil. High proportions of VED provide evidence that this nutritional deficiency is a public health problem in children and still little addressed in the international scientific literature. The planning, evaluation and implementation of health policies aimed at combatting VED in the paediatric population are extremely important.<\/jats:p>","DOI":"10.1017\/s0954422422000142","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T09:14:58Z","timestamp":1659690898000},"page":"392-405","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin E deficiency in childhood: a narrative review"],"prefix":"10.1017","volume":"36","author":[{"given":"Lina Monteiro de Castro","family":"Lobo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-8629","authenticated-orcid":false,"given":"Maria Claret Costa Monteiro","family":"Hadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"S0954422422000142_ref41","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.2.263"},{"key":"S0954422422000142_ref45","doi-asserted-by":"publisher","DOI":"10.1159\/000343106"},{"key":"S0954422422000142_ref127","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600552"},{"key":"S0954422422000142_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/156482651103200206"},{"key":"S0954422422000142_ref46","first-page":"396","volume-title":"Modern Nutrition in Health and Disease","author":"Traber","year":"2006"},{"key":"S0954422422000142_ref61","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800121200"},{"key":"S0954422422000142_ref56","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/47.1.39"},{"key":"S0954422422000142_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.06.012"},{"key":"S0954422422000142_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.04.006"},{"key":"S0954422422000142_ref94","first-page":"1","article-title":"Multiple micronutrient powder reduces vitamin E deficiency in Brazilian children: a pragmatic, controlled clinical trial","volume":"11","author":"Lobo","year":"2019","journal-title":"Nutrients"},{"key":"S0954422422000142_ref43","doi-asserted-by":"publisher","DOI":"10.1079\/NRR19940008"},{"key":"S0954422422000142_ref51","doi-asserted-by":"publisher","DOI":"10.1002\/9781119946045.ch14"},{"key":"S0954422422000142_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12026"},{"key":"S0954422422000142_ref74","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:79:2:115"},{"key":"S0954422422000142_ref132","first-page":"1","article-title":"Food fortification with multiple micronutrientes: impact on health outcomes in general population","volume":"1","author":"Das","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"S0954422422000142_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.03.035"},{"key":"S0954422422000142_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.01.001"},{"key":"S0954422422000142_ref96","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000323"},{"key":"S0954422422000142_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665199000609"},{"key":"S0954422422000142_ref52","first-page":"1","article-title":"Scientific opinion on dietary reference values for vitamin E as \u03b1-tocopherol","volume":"13","year":"2015","journal-title":"EFSA J"},{"key":"S0954422422000142_ref116","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842010005000069"},{"key":"S0954422422000142_ref84","first-page":"1","article-title":"Effect of providing multiple micronutrients in powder through primary healthcare on anemia in young Brazilian children: a multi-centre pragmatic controlled trial","volume":"11","author":"Cardoso","year":"2016","journal-title":"PLos ONE"},{"key":"S0954422422000142_ref92","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.660S"},{"key":"S0954422422000142_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813050-6.00004-8"},{"key":"S0954422422000142_ref78","first-page":"178","article-title":"Micronutrient status of primary school girls in rural and urban areas of South Vietnam","volume":"12","author":"Mai","year":"2003","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0954422422000142_ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00301.2015"},{"key":"S0954422422000142_ref20","volume-title":"Cohen C, Silva CS, Vannucchi H. 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