{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:24:52Z","timestamp":1793744692143,"version":"4.6.1"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Nutr. Res. Rev."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autism spectrum disorder (ASD) is a neurodevelopmental condition. Omega-3 fatty acid insufficiency has been linked to ASD. This umbrella meta-analysis was performed to investigate the effects of omega-3 supplementation on clinical manifestations in participants with ASD. Based on the PRISMA statement, databases including Web of Science, PubMed and Scopus were systematically searched for published meta-analyses on the effect of omega-3 supplementation on ASD up to December 2023. To assess the risk of bias, the assessment of multiple systematic reviews (AMSTAR)-2 was utilised. The outcomes were core and non-core symptoms of ASD including social withdrawal\/lethargy, cluttering speech, hyperactivity, irritability and stereotypy. Seven meta-analyses eventually remained in the umbrella review. The results revealed that omega-3 fatty acid supplementation caused a significant reduction in cluttering speech in studies conducted on age \u22648 years (effect size (ES)\u00a0\u22120\u00b730; 95% confidence interval (CI) \u22120\u00b755, \u22120\u00b706;\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b702). Omega-3 supplementation caused a significant reduction in hyperactivity in participants \u22648 years (ES\u00a0\u22120\u00b730; 95% CI \u22120\u00b755, \u22120\u00b706;\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b702) and in participants who received the supplements for more than 14 weeks (ES\u00a0\u22120\u00b730; 95% CI \u22120\u00b755, \u22120\u00b706;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b702). A dosage of \u22641000\u00a0mg\/d of omega-3 supplementation led to a significant increase in the stereotypy\/restricted and repetitive interests and behaviours (ES\u00a00\u00b719; 95% CI 0\u00b703, 0\u00b735;\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b702). This umbrella review revealed that omega-3 fatty acid may be a beneficial supplement to control cluttering speech and hyperactivity in children with ASD who are 8 years old or younger.\n                  <\/jats:p>","DOI":"10.1017\/s0954422424000325","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T02:06:04Z","timestamp":1732154764000},"page":"546-557","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Impact of omega-3 fatty acid supplementation on clinical manifestations in autism spectrum disorders: an umbrella review of meta-analyses"],"prefix":"10.1017","volume":"38","author":[{"given":"Hamid","family":"Abbasi","sequence":"first","affiliation":[{"name":"Tabriz University of Medical Sciences"},{"name":"Tabriz University of Medical 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