{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:07:00Z","timestamp":1790888820785,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>This is a critical review of the literature related to the neurodevelopmental hypothesis of\nschizophrenia which posits that the illness is related to abnormal brain development. The review\nfocuses on data deriving from clinical studies, and it is organized according to the life phase from\nwhich the data were collected: conception and birth, infancy and childhood up to the onset of the\nillness, after illness onset, and postmortem. The neurodevelopmental hypothesis is supported by\nseveral pieces of evidence, including increased frequency of obstetric complications in patients\nwith schizophrenia; the presence of minor physical anomalies; the presence of neurological,\ncognitive, and behavioral dysfunction long before illness onset; a course and outcome of the\nillness itself that is incompatible in most cases with a degenerative illness; the stability of brain\nstructural measures over time; and the absence of postmortem evidence of neurodegeneration. A\nhistorical perspective on how this research accumulated and a section addressing important areas\nof future investigation are also provided. We conclude that schizophrenia is certainly not a\ndegenerative brain disorder, and that it is likely that a brain insult in utero or at birth plays a role\nin its expression. Current evidence cannot completely exclude the role of environmental\nvariables after birth. In addition, it is possible that other psychiatric disorders may also have a\nneurodevelopmental component.<\/jats:p>","DOI":"10.1017\/s0954579400003138","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:47:49Z","timestamp":1027777669000},"page":"501-527","source":"Crossref","is-referenced-by-count":373,"title":["The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from\ncradle to grave"],"prefix":"10.1017","volume":"12","author":[{"given":"STEFANO","family":"MARENCO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIEL R.","family":"WEINBERGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,9,1]]},"container-title":["Development and Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954579400003138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T19:25:38Z","timestamp":1554233138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954579400003138\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0954579400003138"],"URL":"https:\/\/doi.org\/10.1017\/s0954579400003138","relation":{},"ISSN":["0954-5794","1469-2198"],"issn-type":[{"value":"0954-5794","type":"print"},{"value":"1469-2198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}