{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:06:20Z","timestamp":1789020380014,"version":"build-2803163510"},"reference-count":171,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"unspecified","delay-in-days":11,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>\n                    The aim of this paper is to clarify how neural mechanisms at the \nmolecular level, specifically the serotonergic (5-HT) system and the \nhypothalamic\u2013pituitary\u2013adrenal axis system (HPA) in \nconjunction with early life stress may contribute to the emergence of \naggression, self-directed and otherwise, in borderline personality \ndisorder (BPD). Chronic dysregulation of these biological systems, which \nfunction to regulate stress and emotion, may potentiate the development of \nimpulsive aggression in borderline personality conditions. Our central \npremise in this paper is that brain development, stress regulation, and \nearly pathonomic experience are interactive and cumulative in their mutual \ninfluence on the development of impulsive aggression in BPD. We review the \nparameters of impulsive aggression in BPD, followed by a discussion of the \nneurobiological and neuroendocrine correlates of impulsive aggression with \nand without BPD. We then focus on the developmental continuities in BPD \nwith attention to brain maturation of 5-HT and HPA axis function during \nthe life span and the influence of early adverse experiences on these \nsystems. Finally, we comment on the data of the relative stability of \naggression in BPD, adolescence as a developmental stage of potential \nvulnerability, and the course of aggressive behavior during the life \nspan.\n                    <jats:fn>\n                      <jats:p>The authors thank Caroline Cozza, \nMichael McCloskey, and Kurt Knoblett for their comments during the \npreparation of this manuscript. This research was supported by research \nfunding from the American Foundation of Suicide Prevention (J.K.G.), Grant \nMH066888-01 (R.L.), and the Borderline Personality Disorder Research \nFoundation (E.F.C.).<\/jats:p>\n                    <\/jats:fn>\n                  <\/jats:p>","DOI":"10.1017\/s0954579405050546","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T07:27:09Z","timestamp":1208762829000},"page":"1151-1171","source":"Crossref","is-referenced-by-count":42,"title":["Developmental psychopathology and neurobiology of aggression"],"prefix":"10.1017","volume":"17","author":[{"given":"JACKIE K.","family":"GOLLAN","sequence":"first","affiliation":[{"name":"University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROYCE","family":"LEE","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMIL F.","family":"COCCARO","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"S0954579405050546_ref083","doi-asserted-by":"crossref","unstructured":"Kraemer, G. 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