{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:06:33Z","timestamp":1789020393169,"version":"build-2803163510"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"unspecified","delay-in-days":283,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Consistent evidence shows both genetic and stress-related risks on child and adolescent anxiety, yet few studies have considered the degree to which genetic effects are moderated by stress (gene\u2013environment interaction). We used longitudinal data from both a child and adolescent sample of twins to examine three novel issues on the presence of gene\u2013environment interaction on anxiety symptoms. First, we assessed moderation of genetic risks on anxiety symptoms by negative life events in each age group. Second, by distinguishing between \u201cstable\u201d and \u201cage-specific\u201d genetic factors, we explored the continuity of gene\u2013environment interaction across time and\/or its emergence at specific ages. Third, we compared the presence of gene\u2013environment interaction across different symptom types (general, panic, social, and separation). Genetic effects on separation anxiety symptoms in childhood (mean age = 8 years, 6 months) and panic anxiety symptoms in adolescence (mean age = 15 years) increased across independent negative life events. Shared environmental effects on separation anxiety symptoms and nonshared environmental effects on general anxiety symptoms in adolescence were also moderated by negative life events. We interpret these preliminary findings tentatively in the context of gene\u2013environment interaction on anxiety in general, and on early separation and later panic anxiety in particular.<\/jats:p>","DOI":"10.1017\/s0954579407000582","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T09:07:55Z","timestamp":1192093675000},"page":"1129-1146","source":"Crossref","is-referenced-by-count":58,"title":["Assessing gene\u2013environment interactions on anxiety symptom subtypes across childhood and adolescence"],"prefix":"10.1017","volume":"19","author":[{"given":"Jennifer Y. 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