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The primary aim of this paper is to discuss the evidence that specific neurobiological systems are involved in the etiology of childhood-onset antisocial behavior. These factors are responsible for the severity of the behavioral problems observed in antisocial children, but they also play a role in their persistence, because they influence children's interactions with their environment. We will discuss the possible causes of disruptions in neurobiological systems in childhood antisocial behavior and point out the implications of these findings for theory and clinical practice. We will argue that familial factors (e.g., genetic influences, early childhood adversity) are linked to negative behavioral outcomes (e.g., antisocial behavior problems) through the mediating and transactional interplay with neurobiological deficits. An investigation of neurobiological functioning in antisocial children might not only indicate which children are most likely to persist in engaging in severe antisocial behavior, but also guide the development of new interventions.<\/jats:p>","DOI":"10.1017\/s095457940800045x","type":"journal-article","created":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T12:56:07Z","timestamp":1215435367000},"page":"941-973","source":"Crossref","is-referenced-by-count":78,"title":["How can the study of biological processes help design new interventions for children with severe antisocial behavior?"],"prefix":"10.1017","volume":"20","author":[{"given":"Stephanie H. 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