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Variation in the corticotropin releasing hormone receptor 1<jats:italic>(CRHR1)<\/jats:italic>TAT haplotype and serotonin transporter linked polymorphic region (<jats:italic>5-HTTLPR<\/jats:italic>) was determined in a sample of maltreated (<jats:italic>n<\/jats:italic>= 238, 21.4% with early physical and sexual abuse) and nonmaltreated (<jats:italic>n<\/jats:italic>= 255) children (<jats:italic>M<\/jats:italic>age = 10.08) participating in a summer research camp. Internalizing and depressive symptoms were assessed by other and self-report. G \u00d7 E effects for<jats:italic>CRHR1<\/jats:italic>and maltreatment and early abuse on diurnal cortisol regulation were observed;<jats:italic>CRHR1<\/jats:italic>variation was related to cortisol dysregulation only among maltreated children. Early abuse and high internalizing symptoms also interacted to predict atypical diurnal cortisol regulation. The interaction of<jats:italic>CRHR1, 5-HTTLPR<\/jats:italic>, and child maltreatment (G \u00d7 G \u00d7 E) identified a subgroup of maltreated children with high internalizing symptoms who shared the same combination of the two genes. 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