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The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (<jats:italic>N<\/jats:italic>= 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders.<\/jats:p>","DOI":"10.1017\/s0954579413000382","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T11:22:13Z","timestamp":1383909733000},"page":"1079-1091","source":"Crossref","is-referenced-by-count":7,"title":["The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents"],"prefix":"10.1017","volume":"25","author":[{"given":"Bonnie","family":"Klimes-Dougan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher David","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro E.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,11,8]]},"reference":[{"key":"S0954579413000382_ref71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00655.x"},{"key":"S0954579413000382_ref60","volume-title":"Children of depressed mothers: From early childhood to maturity","author":"Radke-Yarrow","year":"1998"},{"key":"S0954579413000382_ref53","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-011-0227-x"},{"key":"S0954579413000382_ref3","volume-title":"Manual for the Child Behavior Checklist\/4\u201318 and 1991 profile","author":"Achenbach","year":"1991"},{"key":"S0954579413000382_ref15","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.41.s128"},{"key":"S0954579413000382_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.20011"},{"key":"S0954579413000382_ref34","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/jclp.20695","article-title":"Discrepancies between adolescent, mother, and father reports of adolescent internalizing symptom levels and their association with parent symptoms","volume":"66","author":"Hughes","year":"2010","journal-title":"Journal of Clinical Psychology"},{"key":"S0954579413000382_ref44","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579410000507"},{"key":"S0954579413000382_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770060086012"},{"key":"S0954579413000382_ref10","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.112.2.179"},{"key":"S0954579413000382_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"S0954579413000382_ref56","year":"2010","journal-title":"R: A language and environment for statistical computing"},{"key":"S0954579413000382_ref65","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080032005"},{"key":"S0954579413000382_ref26","volume-title":"Applied longitudinal analysis","author":"Fitzmaurice","year":"2004"},{"key":"S0954579413000382_ref13","first-page":"1","volume-title":"Understanding bipolar disorder: A developmental psychopathology perspective","author":"Cicchetti","year":"2010"},{"key":"S0954579413000382_ref6","first-page":"35","article-title":"Adolescent self-report of emotional and behavioral problems: Interactions of genetic factors with sex and age","volume":"20","author":"Bartels","year":"2011","journal-title":"Journal of the Canadian Academy of Child and Adolescent Psychiatry"},{"key":"S0954579413000382_ref37","doi-asserted-by":"publisher","DOI":"10.1177\/1087054709347434"},{"key":"S0954579413000382_ref66","unstructured":"Therneau T. 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