{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:05:53Z","timestamp":1772294753890,"version":"3.50.1"},"reference-count":66,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [<jats:italic>DRD2<\/jats:italic>], dopamine transporter solute carrier family C6, member 4 [<jats:italic>SLC6A3<\/jats:italic>], and catechol-<jats:italic>O<\/jats:italic>-methyltransferase [<jats:italic>COMT<\/jats:italic>]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior. A community sample (<jats:italic>N<\/jats:italic>= 193) of mother\u2013infant dyads participated in a toy frustration challenge at infant age 15 months, and infant emotion regulation behavior was coded. Buccal cells were collected for genotyping. Maternal maltreatment history significantly interacted with infant<jats:italic>SLC6A3<\/jats:italic>and<jats:italic>COMT<\/jats:italic>genotypes, such that infants with more 10-repeat and valine alleles of<jats:italic>SLC6A3<\/jats:italic>and<jats:italic>COMT,<\/jats:italic>respectively, relative to infants with fewer or no 10-repeat and valine alleles, utilized more independent (i.e., maladaptive) regulatory behavior if mother reported a more extensive maltreatment history, as opposed to less. The findings indicate that child genetic factors moderate the intergenerational impact of maternal maltreatment history. The results are discussed in terms of potential mechanism of Gene \u00d7 Environment interaction.<\/jats:p>","DOI":"10.1017\/s0954579417001122","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T02:34:33Z","timestamp":1502678073000},"page":"581-592","source":"Crossref","is-referenced-by-count":15,"title":["Dopamine receptor D2 (<i>DRD2<\/i>), dopamine transporter solute carrier family C6, member 4 (<i>SLC6A3<\/i>), and catechol-<i>O<\/i>-methyltransferase (<i>COMT<\/i>) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation"],"prefix":"10.1017","volume":"30","author":[{"given":"Vanessa","family":"Villani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Ludmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Levitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo S.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Wekerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"S0954579417001122_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.08.001"},{"key":"S0954579417001122_ref25","doi-asserted-by":"publisher","DOI":"10.1207\/S15327078IN0302_3"},{"key":"S0954579417001122_ref19","volume-title":"Rochester symposium on developmental psychopathology: The emergence of a discipline","volume":"Vol. 1","author":"Cicchetti","year":"1989"},{"key":"S0954579417001122_ref41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02166.x"},{"key":"S0954579417001122_ref36","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.25.3.343"},{"key":"S0954579417001122_ref35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/icd.1916","article-title":"Infant emotion regulation strategy moderates relations between self-reported maternal depressive symptoms and infant HPA activity","volume":"25","author":"Khoury","year":"2015","journal-title":"Infant and Child Development"},{"key":"S0954579417001122_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2008.01979.x"},{"key":"S0954579417001122_ref58","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000185824.57690.f0"},{"key":"S0954579417001122_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2012.01.006"},{"key":"S0954579417001122_ref29","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181ad1c8b"},{"key":"S0954579417001122_ref45","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579407000545"},{"key":"S0954579417001122_ref27","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11020191"},{"key":"S0954579417001122_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8624.00337"},{"key":"S0954579417001122_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.08.026"},{"key":"S0954579417001122_ref33","doi-asserted-by":"publisher","DOI":"10.1037\/a0018180"},{"key":"S0954579417001122_ref38","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.5.585"},{"key":"S0954579417001122_ref57","first-page":"37","volume-title":"Advances in developmental psychology","volume":"1","author":"Rothbart","year":"1981"},{"key":"S0954579417001122_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2008.01194.x"},{"key":"S0954579417001122_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.006"},{"key":"S0954579417001122_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.05.004"},{"key":"S0954579417001122_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2004.01.011"},{"key":"S0954579417001122_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2003.07.006"},{"key":"S0954579417001122_ref10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.eurpsy.2008.10.003","article-title":"The BDI-II factor structure in pregnancy and postpartum: Two or three factors?","volume":"24","author":"Bos","year":"2009","journal-title":"European Psychiatry"},{"key":"S0954579417001122_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.04.006"},{"key":"S0954579417001122_ref26","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.10.2.83"},{"key":"S0954579417001122_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12520-2"},{"key":"S0954579417001122_ref51","doi-asserted-by":"publisher","DOI":"10.2307\/1130851"},{"key":"S0954579417001122_ref6","doi-asserted-by":"publisher","DOI":"10.1037\/a0017376"},{"key":"S0954579417001122_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80138-7"},{"key":"S0954579417001122_ref32","doi-asserted-by":"publisher","DOI":"10.1080\/15295192.2012.683341"},{"key":"S0954579417001122_ref5","volume-title":"Manual for the Beck Depression Inventory","author":"Beck","year":"1996"},{"key":"S0954579417001122_ref39","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1988.10478722"},{"key":"S0954579417001122_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00040-3"},{"key":"S0954579417001122_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.002"},{"key":"S0954579417001122_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02126.x"},{"key":"S0954579417001122_ref62","doi-asserted-by":"publisher","DOI":"10.1207\/S15327752JPA8003_01"},{"key":"S0954579417001122_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.006"},{"key":"S0954579417001122_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9507.00098"},{"key":"S0954579417001122_ref23","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.6.4.330"},{"key":"S0954579417001122_ref60","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000002"},{"key":"S0954579417001122_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579411000162"},{"key":"S0954579417001122_ref56","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579412000065"},{"key":"S0954579417001122_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12408"},{"key":"S0954579417001122_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.09.006"},{"key":"S0954579417001122_ref46","doi-asserted-by":"publisher","DOI":"10.1177\/0886260512455868"},{"key":"S0954579417001122_ref47","doi-asserted-by":"publisher","DOI":"10.1177\/1077801212475337"},{"key":"S0954579417001122_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"S0954579417001122_ref7","volume-title":"Childhood Trauma Questionnaire: A retrospective self-report. Professional manual","author":"Bernstein","year":"1998"},{"key":"S0954579417001122_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181b52930"},{"key":"S0954579417001122_ref63","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199231881.001.0001"},{"key":"S0954579417001122_ref48","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004564"},{"key":"S0954579417001122_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579406060329"},{"key":"S0954579417001122_ref8","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"American Journal of Psychiatry"},{"key":"S0954579417001122_ref4","first-page":"27","volume-title":"Attachement et d\u00e9veloppement: Le r\u00f4le des premieres relations dans le d\u00e9veloppement humain","author":"Atkinson","year":"2000"},{"key":"S0954579417001122_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12128"},{"key":"S0954579417001122_ref44","doi-asserted-by":"publisher","DOI":"10.1177\/1077559511415091"},{"key":"S0954579417001122_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579407070186"},{"key":"S0954579417001122_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(91)90002-7"},{"key":"S0954579417001122_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(01)00286-1"},{"key":"S0954579417001122_ref53","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.160"},{"key":"S0954579417001122_ref13","doi-asserted-by":"publisher","DOI":"10.2307\/1131730"},{"key":"S0954579417001122_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00010-1"},{"key":"S0954579417001122_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.05.059"},{"key":"S0954579417001122_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001869"},{"key":"S0954579417001122_ref1","volume-title":"Patterns of attachment: A psychological study of the strange situation","author":"Ainsworth","year":"1978"},{"key":"S0954579417001122_ref61","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.31.3.448"}],"container-title":["Development and Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954579417001122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T06:54:43Z","timestamp":1719384883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954579417001122\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0954579417001122"],"URL":"https:\/\/doi.org\/10.1017\/s0954579417001122","relation":{},"ISSN":["0954-5794","1469-2198"],"issn-type":[{"value":"0954-5794","type":"print"},{"value":"1469-2198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]}}}