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This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (<jats:italic>n<\/jats:italic> = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group \u00d7 Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE.<\/jats:p>","DOI":"10.1017\/s0954579420001613","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:24:37Z","timestamp":1610695477000},"page":"1013-1024","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-2651","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Deuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion-Hideo","family":"Breden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"V\u00f6gele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Wingenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Otte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-6302","authenticated-orcid":false,"given":"Linn K.","family":"Kuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"S0954579420001613_ref88","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1016\/j.psyneuen.2013.06.027","article-title":"Cortisol rapidly affects amplitudes of heartbeat-evoked brain potentials-Implications for the contribution of stress to an altered perception of physical sensations?","volume":"38","author":"Schulz","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"S0954579420001613_ref94","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.clinph.2012.02.086","article-title":"Heartbeat evoked potentials mirror altered body perception in depressed patients","volume":"123","author":"Terhaar","year":"2012","journal-title":"Clinical Neurophysiology"},{"key":"S0954579420001613_ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the Childhood Trauma Questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse and Neglect"},{"key":"S0954579420001613_ref99","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1026\/0012-1924\/a000036","article-title":"Die deutsche Version des \u201cEarly Trauma Inventory\u201d (ETI). 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