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To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9\u201310, who participated in the baseline session of the Adolescent Brain Cognitive Development<jats:sup>SM<\/jats:sup> Study (ABCD Study\u00ae). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (\u03b2 = .039, 95% CI<jats:sub>corrected<\/jats:sub> [.0027 .0771]), but lower Degree<jats:sub>subcortical<\/jats:sub> (\u03b2 = \u2212.052, 95% CI<jats:sub>corrected<\/jats:sub> [\u2212.0916 \u2212.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (\u03b2 = \u2212.104, 95% CI [\u2212.1328 \u2212.0763]) and an emotion recognition memory assessment (\u03b2 = \u2212.061, 95% CI [\u2212.0919 \u2212.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect \u03b2 = \u2212.002, 95% CI [\u2212.0044 \u2212.0002]), and Degree<jats:sub>subcortical<\/jats:sub> mediated the relationship between CD and emotion recognition memory performance (indirect \u03b2 = \u2212.002, 95% CI [\u2212.0046 \u2212.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions.<\/jats:p>","DOI":"10.1017\/s0954579421000237","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T13:45:28Z","timestamp":1618407928000},"page":"1573-1584","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-5718","authenticated-orcid":false,"given":"Scott","family":"Tillem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May I.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Baskin-Sommers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"S0954579421000237_ref2","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1002\/hbm.23292","article-title":"Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders","volume":"37","author":"Aghajani","year":"2016","journal-title":"Human Brain Mapping"},{"key":"S0954579421000237_ref83","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S135561771400040X","article-title":"NIH toolbox cognition battery (NIHTB-CB): The list sorting test to measure working memory","volume":"20","author":"Tulsky","year":"2014","journal-title":"Journal of the International Neuropsychological Society"},{"key":"S0954579421000237_ref63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0272-7358(98)00096-8","article-title":"A meta-analytic review of the relation between antisocial behavior and neuropsychological measures of executive function","volume":"20","author":"Morgan","year":"2000","journal-title":"Clinical Psychology Review"},{"key":"S0954579421000237_ref3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/mono.12038","article-title":"VIII. 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