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While many interesting proposals are competing for attention in the literature, they tend to focus narrowly on the proximate level of analysis and lack a broader understanding of biological function. In this paper, we present an integrative framework for mental disorders built on concepts from life history theory, and describe a taxonomy of mental disorders based on its principles, the<jats:italic>fast\u2013slow\u2013defense<\/jats:italic>model (FSD). The FSD integrates psychopathology with normative individual differences in personality and behavior, and allows researchers to draw principled distinctions between broad clusters of disorders, as well as identify functional subtypes within current diagnostic categories. Simulation work demonstrates that the model can explain the large-scale structure of comorbidity, including the apparent emergence of a general \u201cp factor\u201d of psychopathology. A life history approach also provides novel integrative insights into the role of environmental risk\/protective factors and the developmental trajectories of various disorders.<\/jats:p>","DOI":"10.1017\/s0954579421000870","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T08:37:41Z","timestamp":1628498261000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":29,"title":["An integrative evolutionary framework for psychopathology"],"prefix":"10.1017","volume":"35","author":[{"given":"Marco","family":"Del Giudice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-6219","authenticated-orcid":false,"given":"John 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