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Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (<jats:italic>n<\/jats:italic>\u00a0=\u00a058 maltreated; <jats:italic>n<\/jats:italic>\u00a0=\u00a040 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence (\u226413.5 years, <jats:italic>n<\/jats:italic>\u00a0=\u00a050; &gt;13.5 years, <jats:italic>n<\/jats:italic>\u00a0=\u00a048). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex\/pre-supplementary motor area (dACC\/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC\/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus\/posterior cingulate cortex.<\/jats:p>","DOI":"10.1017\/s0954579421001681","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T09:28:41Z","timestamp":1643794121000},"page":"573-585","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1082-4877","authenticated-orcid":false,"given":"Charlotte C.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"von Klitzing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Deserno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-4342","authenticated-orcid":false,"given":"Margaret A.","family":"Sheridan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margerete J. 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