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In this exploratory three-wave longitudinal study spanning ages 9\u201319 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms.<\/jats:p>","DOI":"10.1017\/s0954579421001814","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T09:08:46Z","timestamp":1643620126000},"page":"557-571","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":76,"title":["An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0985-5622","authenticated-orcid":false,"given":"Rajpreet","family":"Chahal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-3900","authenticated-orcid":false,"given":"Jonas G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-0432","authenticated-orcid":false,"given":"Justin P.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-9418","authenticated-orcid":false,"given":"Jessica L.","family":"Buthmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-3199","authenticated-orcid":false,"given":"Ian H.","family":"Gotlib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"S0954579421001814_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116493"},{"key":"S0954579421001814_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104651"},{"key":"S0954579421001814_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01391.x"},{"key":"S0954579421001814_ref48","doi-asserted-by":"crossref","unstructured":"Ribbe, D. 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