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Data are from 854 male and female, same-sex adult twin pairs born between 1926 and 1971 (32\u201360 years old, <jats:italic>M<\/jats:italic> = 44.9 years, <jats:italic>SD<\/jats:italic> = 4.9 years) from the Twin and Offspring Study in Sweden and their adolescent offspring (11\u201322 years old, <jats:italic>M<\/jats:italic> = 15.7 years, <jats:italic>SD<\/jats:italic> = 2.4 years, 52% female). Children-of-twins models revealed additive (9%) and dominant (45%) genetic and nonshared environmental (47%) influences on twins\u2019 symptom severity, and additive genetic (39%) and nonshared environmental (61%) influences on twins\u2019 symptom directionality. Both comorbid problems and preponderance of symptoms of a particular \u2013 internalizing versus externalizing \u2013 spectrum were correlated across parent and child generations, although associations were modest especially for directionality (i.e., transmission of specific symptom type). By interpreting findings alongside a recent study of adolescent twins, we demonstrate that the intergenerational transmission of symptom severity and symptom directionality are both unlikely to be attributable to genetic transmission, are both likely to be influenced by direct phenotypic transmission and\/or nonpassive <jats:italic>r<\/jats:italic>GE, and the intergenerational transmission of symptom severity is also likely to be influenced by passive <jats:italic>r<\/jats:italic>GE.<\/jats:p>","DOI":"10.1017\/s0954579422000852","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T07:50:54Z","timestamp":1663055454000},"page":"1767-1780","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Intergenerational transmission of psychopathology: An examination of symptom severity and 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