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ALEs were operationalized as broad (e.g., moving, parental divorce, family sickness) or physically threatening (physical and\/or sexual abuse). First, we examined lifetime ALEs, followed by an investigation into their timing. The sample consisted of 909 adolescents (aged 12\u201318 years) from a cohort oversampled on high levels of emotional and behavioral problems. The primary caregiver indicated which ALEs each adolescent experienced across their lifetime. Adolescents self-reported on number and frequency of substances used. Poisson and ordinal regression models were used to model the associations. The associations between lifetime ALEs and a substance used were observed only for physical ALEs (incidence rate ratio 1.18 [1.03, 1.35], <jats:italic>p<\/jats:italic> = 0.02). When investigating timing, physical ALEs after the age of 12 predicted number of substances used (IRR 1.36 [1.13, 1.63], <jats:italic>p<\/jats:italic> &lt; .001). Recent ALEs (occurring after age 12) seem to have considerable impact on substance use. Alcohol and drugs as a coping mechanism were considered a plausible explanation for the results.<\/jats:p>","DOI":"10.1017\/s095457942300086x","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T05:55:37Z","timestamp":1690782937000},"page":"1606-1615","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Timing and type of adverse life events: Impact on substance use among high-risk adolescents"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2043-8566","authenticated-orcid":false,"given":"Milan","family":"Zarchev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"Kamperman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"El 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