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Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging \u2013 a measure of methylation differences that are associated with infant health outcomes \u2013 moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL\/1.5\u20135 when offspring were 2\u20134 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (<jats:italic>p<\/jats:italic>s = 0.003\u20130.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology.<\/jats:p>","DOI":"10.1017\/s0954579423001232","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:19:26Z","timestamp":1695964766000},"page":"1890-1902","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-1448","authenticated-orcid":false,"given":"Brooke G.","family":"McKenna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia 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