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Drawing from the United Kingdom\u2019s Millennium Cohort Study (<jats:italic>N<\/jats:italic> = 19,444), we identified eight unique profiles of early childhood adversity and protective factors. These profiles provide a nuanced understanding of adversity combinations and allow for differentiation between groups with similar profiles. Latent profile membership was a significant predictor of all adolescent outcome variables, indicating that profiles differed significantly from one another on psychosocial and behavioral outcomes (Wald values ranged from 10.10\u2013623.22; <jats:italic>p<\/jats:italic> &lt; .001). Some findings support the cumulative risk model, indicating that exposure to multiple early adversities increases the likelihood of adverse outcomes. However, we also found that specific adversities, such as parental psychopathology, parental alcohol use, and neighborhood deprivation, uniquely impact adolescent outcomes. This study highlights the necessity for tailored interventions and policies to support children with distinct early life experiences, emphasizing the importance of addressing both cumulative and specific adversities at multiple levels to prevent psychosocial and behavioral problems in adolescence.<\/jats:p>","DOI":"10.1017\/s0954579424001561","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:23:20Z","timestamp":1729059800000},"page":"1543-1555","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Patterns of early childhood adversity and neighborhood deprivation predict unique challenges in adolescence: A UK birth cohort study"],"prefix":"10.1017","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-9016","authenticated-orcid":false,"given":"Zhenyu Z.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Bayly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"S0954579424001561_ref18","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s10826-020-01731-3","article-title":"The protective effect of emotion regulation on child and adolescent wellbeing","volume":"29","author":"Daniel","year":"2020","journal-title":"Journal of Child and Family Studies"},{"key":"S0954579424001561_ref15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.addbeh.2009.09.013","article-title":"A cognitive model for the intergenerational transference of alcohol use behavior","volume":"35","author":"Campbell","year":"2010","journal-title":"Addictive Behaviors"},{"key":"S0954579424001561_ref75","unstructured":"Melhuish, E. , Quinn, L. , Hanna, K. , Sylva, K. , Sammons, P. , Siraj-Blatchford, I. , & Taggart, B. 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