{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:59:59Z","timestamp":1790935199188,"version":"4.1.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal internalizing (anxiety and depressive) symptoms are a robust risk factor for the development of internalizing symptoms in offspring, yet the neurobiological mechanisms that influence this association remain relatively unexplored. The aperiodic \u201cslope\u201d of the EEG power spectrum (i.e., aperiodic exponent) is hypothesized to index the cortical excitatory-inhibitory balance and may serve as an early neurophysiological marker of mental health risk. In a prospective longitudinal cohort (\n                    <jats:italic>N<\/jats:italic>\n                    = 323 mother\u2013child dyads), we examined associations among maternal anxiety and depressive symptoms in infancy and at age 5 years, child EEG aperiodic slope at age 3 years, and child internalizing symptoms at age 5 years. We investigated whether the aperiodic slope at 3 years (a) mediated associations between maternal internalizing symptoms in infancy and child internalizing symptoms at age 5 years and\/or (b) moderated associations between maternal internalizing symptoms and child internalizing symptoms at age 5 years. There were no significant mediation effects. The aperiodic slope moderated the association between maternal anxiety symptoms and child internalizing symptoms: A steeper slope was associated with a stronger association between maternal and child symptoms. Findings suggest that the EEG aperiodic slope may represent a moderator of intergenerational risk for internalizing symptoms in early childhood.\n                  <\/jats:p>","DOI":"10.1017\/s0954579426101400","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:54:21Z","timestamp":1778219661000},"page":"1668-1676","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Neurophysiological sensitivity in early childhood: EEG aperiodic slope moderates the association between maternal anxiety and child internalizing symptoms"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-1301","authenticated-orcid":false,"given":"Dashiell D.","family":"Sacks","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dvg7y05","id-type":"ROR","asserted-by":"publisher"}],"name":"Boston Children\u2019s Hospital"},{"id":[{"id":"https:\/\/ror.org\/03vek6s52","id-type":"ROR","asserted-by":"publisher"}],"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-3877","authenticated-orcid":false,"given":"Viviane","family":"Valdes","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital"},{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April R.","family":"Levin","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital"},{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-247X","authenticated-orcid":false,"given":"Charles A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital"},{"name":"Harvard Medical School"},{"name":"Harvard Graduate School of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-3894","authenticated-orcid":false,"given":"Michelle","family":"Bosquet Enlow","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dvg7y05","id-type":"ROR","asserted-by":"publisher"}],"name":"Boston Children\u2019s Hospital"},{"id":[{"id":"https:\/\/ror.org\/03vek6s52","id-type":"ROR","asserted-by":"publisher"}],"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"S0954579426101400_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579424001858"},{"key":"S0954579426101400_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01618.x"},{"key":"S0954579426101400_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"S0954579426101400_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-010-0080-1"},{"key":"S0954579426101400_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14757"},{"key":"S0954579426101400_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00744-x"},{"key":"S0954579426101400_ref33","volume-title":"Introduction to mediation, moderation, and conditional process analysis: A regression-based approach","author":"Hayes","year":"2022"},{"key":"S0954579426101400_ref1","volume-title":"Manual for the ASEBA school-age forms and profiles","author":"Achenbach","year":"2001"},{"key":"S0954579426101400_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.2482"},{"key":"S0954579426101400_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.119925"},{"key":"S0954579426101400_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796023000756"},{"key":"S0954579426101400_ref23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4637-10.2011"},{"key":"S0954579426101400_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.49568"},{"key":"S0954579426101400_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00513"},{"key":"S0954579426101400_ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00097"},{"key":"S0954579426101400_ref28","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2015.7319296"},{"key":"S0954579426101400_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.14129"},{"key":"S0954579426101400_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.14261"},{"key":"S0954579426101400_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.06.078"},{"key":"S0954579426101400_ref15","doi-asserted-by":"publisher","DOI":"10.5993\/AJHB.43.1.15"},{"key":"S0954579426101400_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/0013164402062004005"},{"key":"S0954579426101400_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.294"},{"key":"S0954579426101400_ref3","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"S0954579426101400_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/da.23039"},{"key":"S0954579426101400_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13394"},{"key":"S0954579426101400_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14326"},{"key":"S0954579426101400_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr597"},{"key":"S0954579426101400_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2010.08.006"},{"key":"S0954579426101400_ref24","volume-title":"Manual for the state-trait anxiety inventory","author":"Spielberger","year":"1983"},{"key":"S0954579426101400_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50204-4"},{"key":"S0954579426101400_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.09.021"},{"key":"S0954579426101400_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2009.06.002"}],"container-title":["Development and Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954579426101400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:39Z","timestamp":1790934399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954579426101400\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0954579426101400"],"URL":"https:\/\/doi.org\/10.1017\/s0954579426101400","relation":{},"ISSN":["0954-5794","1469-2198"],"issn-type":[{"value":"0954-5794","type":"print"},{"value":"1469-2198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}