{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:47:28Z","timestamp":1773236848158,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>Whereas the basic wiring diagram of the mammalian central nervous system (CNS) is\n\ngenetically preprogramed, its fine tuning throughout different phases of infancy, childhood, and\n\nadulthood are highly experience dependent. The potential neurobiological mechanisms and\n\nbehavioral effects of such experience-dependent neuroplasticity as a function of stage of\n\ndevelopment are outlined. A basic thesis of this paper is that mechanisms involved in neuronal\n\nlearning and memory, such as long-term potentiation (LTP) and long-term depression (LTD), are\n\nused and reused not only in the sculpting of the CNS in the initial establishment of connections,\n\nbut also again in the molding of personality and behavior based on experience. It is postulated\n\nthat for higher order processes such as emotional memory, such neuroplasticity is occurring at\n\nincreasingly larger numbers of synapses and cell assemblies with increasing mechanistic\n\ncomplexity and self-organization. Just as overexcitation or deprivation can profoundly affect the\n\ndevelopment of the visual system, it is postulated that similar phenomena exist in the neural\n\nsubstrates of emotional and cognitive development. In addition, a secondary and potentially more\n\nwidespread series of ramifications are likely to occur in the higher order and integrative systems,\n\nsuch as secondary and tertiary cortical association areas and prefrontal cortex that become the\n\nultimate integrators of emotion and experience, leading to subsequent actions and plans for the\n\nfuture. This process is, by definition, plastic, and such remodeling is likely to take place not only\n\nat the level of the single synapse, but also at higher levels of network integration of which we\n\ncurrently have only the barest glimpse. Nonetheless, beginning to discuss the neurobiology of\n\nsuch self-organizing plastic systems may begin to change our conceptual approaches to\n\npsychopathology and open new avenues of therapeutics for the major psychiatric illnesses that\n\nare critically dependent on such higher order learning and memory mechanisms.<\/jats:p>","DOI":"10.1017\/s0954579497001491","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:45:41Z","timestamp":1027777541000},"page":"907-929","source":"Crossref","is-referenced-by-count":42,"title":["Emergent properties of neural systems: How focal molecular neurobiological alterations can\n\naffect behavior"],"prefix":"10.1017","volume":"9","author":[{"given":"ROBERT M.","family":"POST","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN R. B.","family":"WEISS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,12,1]]},"container-title":["Development and Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954579497001491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:42:59Z","timestamp":1557603779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954579497001491\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["S0954579497001491"],"URL":"https:\/\/doi.org\/10.1017\/s0954579497001491","relation":{},"ISSN":["0954-5794","1469-2198"],"issn-type":[{"value":"0954-5794","type":"print"},{"value":"1469-2198","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}