{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:58:04Z","timestamp":1775293084900,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Psychopathol"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>One of the central tenets of developmental psychopathology is the belief that we can\nlearn more about normal functioning through the study of psychopathology and arrive at a better\nunderstanding of pathological conditions through investigations of normal behavior. Advances in\nknowledge from one area will inform us regarding mechanisms at work in the other. A similar\nperspective is the driving force behind recent scientific advances in our understanding of certain\ndevelopmental disorders. In this paper, molecular findings for four developmental disorders are\nreviewed: Prader\u2013Willi syndrome, fragile X syndrome, Williams syndrome, and\nlissencephaly. These disorders were chosen for discussion because putative genes for each of\nthem have been isolated. The ways in which mutations within these genes disrupt normal\ncognitive and behavioral functioning are discussed. Although considerable progress has been\nachieved in understanding the genetic mechanisms for these illnesses, much more research is\nneeded to identify the environmental and genetic factors that interact to contribute to the\nexpression of the more complex behavioral disorders.<\/jats:p>","DOI":"10.1017\/s0954579498001503","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:45:41Z","timestamp":1027777541000},"page":"1-20","source":"Crossref","is-referenced-by-count":9,"title":["Molecular mechanisms of developmental disorders"],"prefix":"10.1017","volume":"10","author":[{"given":"MICHAEL","family":"BRODSKY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL J.","family":"LOMBROSO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,3,1]]},"container-title":["Development and Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0954579498001503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T19:07:12Z","timestamp":1553886432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0954579498001503\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0954579498001503"],"URL":"https:\/\/doi.org\/10.1017\/s0954579498001503","relation":{},"ISSN":["0954-5794","1469-2198"],"issn-type":[{"value":"0954-5794","type":"print"},{"value":"1469-2198","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}