{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:33:33Z","timestamp":1792503213230,"version":"4.5.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Camb Q Healthc Ethics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This essay focuses on the ethical considerations and implications of providing a universal multi-cancer screening test as the best approach to reduce societal cancer burden in a society with limited funds, resources, and infrastructure. With 1.9 million cancer diagnoses each year in the United States, with 86% of all cancers diagnosed in individuals over the age of 50, and with screening tools approved for only four cancer types (breast, cervical, colorectal, and lung cancer), it seems that a multi-cancer screening test to detect most cancer early that is easy to administer, and is accurate and cost-effective, would be worth considering. Whole-body magnetic resonance imaging and a multi-marker blood test are the two main technologies that we will discuss as a universal screening test. However, to understand and appreciate the societal and clinical breakthrough of such a screening test, we must first consider the accessibility and efficacy of current screening methods. We conclude with a closer examination of the ethical implications of implementing the Galleri test as a multi-cancer detection screening tool as adamantly advocated by the company that developed this blood-based test.<\/jats:p>","DOI":"10.1017\/s0963180124000744","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T08:10:32Z","timestamp":1735891832000},"page":"489-498","source":"Crossref","is-referenced-by-count":6,"title":["Ethical Considerations and Implications of Multi-Cancer Early Detection Screening: Reliability, Access and Cost to Test and Treat"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-0122","authenticated-orcid":false,"given":"Lorenzo F.","family":"Sempere","sequence":"first","affiliation":[{"name":"Michigan State University"},{"name":"Michigan State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"S0963180124000744_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.011"},{"key":"S0963180124000744_ref9","first-page":"368","article-title":"Cancer screening with multicancer detection tests: A translational science review","volume":"74","author":"Rubinstein","year":"2024","journal-title":"A: A Cancer Journal for Clinicians"},{"key":"S0963180124000744_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230622"},{"key":"S0963180124000744_ref19","first-page":"e2347006","article-title":"Cancer drug price and novelty in mechanism of action","volume":"6","author":"Miljkovic","year":"2023","journal-title":"Journal of American Medical Association Network Open"},{"key":"S0963180124000744_ref15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143501"},{"key":"S0963180124000744_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00602-5"},{"key":"S0963180124000744_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01392-2"},{"key":"S0963180124000744_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.05.806"},{"key":"S0963180124000744_ref13","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4308"},{"key":"S0963180124000744_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae251"},{"key":"S0963180124000744_ref17","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2024-1013"},{"key":"S0963180124000744_ref10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3247"},{"key":"S0963180124000744_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.q1706"},{"key":"S0963180124000744_ref20","doi-asserted-by":"publisher","DOI":"10.7326\/M24-0123"},{"key":"S0963180124000744_ref21","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1134"},{"key":"S0963180124000744_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-09738-4"},{"key":"S0963180124000744_ref6","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2021.1164"},{"key":"S0963180124000744_ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9011"},{"key":"S0963180124000744_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.564"},{"key":"S0963180124000744_ref3","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1415"},{"key":"S0963180124000744_ref5","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"}],"container-title":["Cambridge Quarterly of Healthcare Ethics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0963180124000744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:00:24Z","timestamp":1761534024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0963180124000744\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0963180124000744"],"URL":"https:\/\/doi.org\/10.1017\/s0963180124000744","relation":{},"ISSN":["0963-1801","1469-2147"],"issn-type":[{"value":"0963-1801","type":"print"},{"value":"1469-2147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]}}}