{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:55:34Z","timestamp":1767858934060,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T00:00:00Z","timestamp":1069891200000},"content-version":"unspecified","delay-in-days":118,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>That a mammalian embryo might influence the maternal \nendocrinological and\/or immunological systems \nwhilst still in the Fallopian tube has long seemed possible \n(Fig. 1). Under normal circumstances, the embryo \ncontains a full diploid complement of genetic information \nand thus the point at issue is just how soon instructions \nin the genome are expressed for trophic purposes. \nIt could be argued from several points of view \nthat it would be biologically prudent for an embryo to \ninfluence the mother whilst still at an early stage of \ndevelopment. Consideration of the extremely intimate \napposition of the zona pellucida and the tubal epithelium \n- perhaps best appreciated in scanning electron \nmicrographs (Fig. 2) - also suggests scope for a mutual \nexchange of signals. Even so, one of the earliest \nrecorded maternal responses to a developing embryo \nis the change in permeability of the capillary bed of the \nuterus that precedes implantation in rodents: this can \nbe demonstrated by the Pontamine blue reaction, a \nseries of bands of dye in the uterine wall corresponding \nto the location of individual embryos, and is \ndetectable in rats on the fourth day after mating \n(Psychoyos, 1960, 1973).<\/jats:p>","DOI":"10.1017\/s0967199403002284","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T16:04:41Z","timestamp":1067011481000},"page":"237-243","source":"Crossref","is-referenced-by-count":13,"title":["Potential amplification of early pregnancy signals by ovarian follicular cells in suspension within the Fallopian tube"],"prefix":"10.1017","volume":"11","author":[{"given":"R.H.F.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Einer-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2003,11,27]]},"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199403002284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T22:49:28Z","timestamp":1557182968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199403002284\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0967199403002284"],"URL":"https:\/\/doi.org\/10.1017\/s0967199403002284","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"value":"0967-1994","type":"print"},{"value":"1469-8730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}