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Administration of chromium VI (1 and 2 mg\/kg as potassium dichromate) through intraperitoneal (i.p.) injection during organogenesis (days 6 to 15 of gestation) in rats revealed embryo- and fetotoxic effects. Reduced fetal weight, retarded fetal development, number of fetuses per mother and high incidences of dead fetuses and resorptions in treated mothers were also observed. Gross morphological abnormalities, such as displayed form of edema, facial defect, lack of tail, hypotrophy, severs subdermal haemorrhage patches and hypotrophy of placenta were observed in fetuses after chromium VI-treated mothers. A skeletal development of fetuses presented an incomplete ossification in nasal, cranium, abdominal or caudal bones in rats treated with 1 mg\/kg of chromium, whereas rats treated with 2 mg\/kg showed ossification and absence of the sacral vertebrae compared with the control. At a higher dose of chromium, histological changes were found in fetuses with atrophy of theirs vital organs. Placental histological observations revealed a pronounced morphological alteration, with atrophy of decidual cells, a degenerated of chorionic villi and hypertrophy of blood lacuna. The present study suggests a risk to the developing embryo when the mother is exposed to a high concentration of chromium VI during organogenesis.<\/jats:p>","DOI":"10.1017\/s0967199410000274","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T09:58:13Z","timestamp":1294221493000},"page":"229-235","source":"Crossref","is-referenced-by-count":27,"title":["Embryotoxicity and fetotoxicity following intraperitoneal administrations of hexavalent chromium to pregnant rats"],"prefix":"10.1017","volume":"19","author":[{"given":"Neila","family":"Marouani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfa","family":"Tebourbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moncef","family":"Mokni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Tahar","family":"Yacoubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Sakly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moncef","family":"Benkhalifa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kh\u00e9mais","family":"Ben Rhouma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,12,21]]},"reference":[{"key":"S0967199410000274_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550130315"},{"key":"S0967199410000274_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/333134a0"},{"key":"S0967199410000274_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00779-7"},{"key":"S0967199410000274_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00034-4"},{"key":"S0967199410000274_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03607-5"},{"key":"S0967199410000274_ref23","doi-asserted-by":"publisher","DOI":"10.3109\/9780203909904"},{"key":"S0967199410000274_ref12","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1998.1276"},{"key":"S0967199410000274_ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000191257"},{"key":"S0967199410000274_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(82)90020-2"},{"key":"S0967199410000274_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90279-N"},{"key":"S0967199410000274_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(96)03812-X"},{"key":"S0967199410000274_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290111"},{"key":"S0967199410000274_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.7.1511"},{"key":"S0967199410000274_ref19","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8140121"},{"key":"S0967199410000274_ref30","first-page":"438","article-title":"Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring","volume":"40","author":"Woodall","year":"1996","journal-title":"Pediatres"},{"key":"S0967199410000274_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20081"},{"key":"S0967199410000274_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.09.028"},{"key":"S0967199410000274_ref29","volume-title":"Toxicological Profile for Chromium","author":"Wilbur","year":"2000"},{"key":"S0967199410000274_ref7","volume-title":"European Union Risk Assessment Report: Chromium Trioxide, Sodium Chromate, Sodium Dichromate, Ammonium Dichromate and Potassium Dichromate","year":"2005"},{"key":"S0967199410000274_ref4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00348855","article-title":"Embryotoxicity of chromium: distribution in pregnant mice and effects on embryonic cells in vitro","volume":"51","author":"Danielsson","year":"1982","journal-title":"Arch. 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