{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:09:29Z","timestamp":1766869769001},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T00:00:00Z","timestamp":1310428800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the study was to evaluate the influence of the chromosome Y structure and <jats:italic>Trp53<\/jats:italic> genotype on semen quality parameters. Mice with partial deletion of the Y chromosome (B10.BR-Y<jats:sup>del<\/jats:sup>) have severely altered sperm head morphology when compared with males that possess the complete Y chromosome (B10.BR). Control males from B10.BR and B10.BR-Y<jats:sup>del<\/jats:sup> mice, and mutant males from B10.BR-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and B10.BR-Y<jats:sup>del<\/jats:sup>-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> experimental groups were used. We assessed testis weight, sperm head abnormalities, viability of spermatozoa (eosin test), percentage of motile and immature sperm, and performed a hypo-osmotic test to detect abnormal tail membrane integrity. Sperm morphology and maturation were controlled by the genes within the deleted region of the Y chromosome. Testis weight was higher in the mutants than in the control males, possibly due to cell accumulation in <jats:italic>Trp53<\/jats:italic>-deficient males as the concentration of sperm was significantly increased in the mutants. An elevated percentage of abnormal sperm was noted in B10.BR-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and B10.BR-Y<jats:sup>del<\/jats:sup>-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> male mice. We suggest that, in <jats:italic>Trp53<\/jats:italic>-deficient mice, the sperm cells that escape apoptosis are the ones that have abnormal morphology. The only sperm quality parameter affected by the interplay between <jats:italic>Trp53<\/jats:italic> and chromosome Y genes was sperm motility, which was elevated in B10.BR-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> males, but remained unchanged in B10.BR-Y<jats:sup>del<\/jats:sup>-<jats:italic>p53<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> males.<\/jats:p>","DOI":"10.1017\/s0967199411000323","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T06:27:59Z","timestamp":1310452079000},"page":"65-70","source":"Crossref","is-referenced-by-count":4,"title":["Is p53 controlling spermatogenesis in male mice with the deletion on the Y chromosome?"],"prefix":"10.1017","volume":"21","author":[{"given":"Tomasz","family":"Lech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniela","family":"Golas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozefa","family":"Styrna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,7,12]]},"reference":[{"key":"S0967199411000323_ref21","first-page":"665","article-title":"p53 controls low DNA damage-dependent premeiotic checkpoint and facilitates DNA repair during spermatogenesis","volume":"10","author":"Schwartz","year":"1999","journal-title":"Cell Growth 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