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Each stage of the process of preimplantation embryonic development is led by important signalling pathways that include very many regulatory molecules, such as primary and secondary messengers. Many studies, both<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>, have shown the importance of the contribution of reactive oxygen species (ROS) as important second messengers in embryo development. ROS may originate from embryo metabolism and\/or oocyte\/embryo surroundings, and their effect on embryonic development is highly variable, depending on the needs of the embryo at each stage of development and on their environment (<jats:italic>in vivo<\/jats:italic>or under<jats:italic>in vitro<\/jats:italic>culture conditions). Other studies have also shown the deleterious effects of ROS in embryo development, when cellular tissue production overwhelms antioxidant production, leading to oxidative stress. This stress is known to be the cause of many cellular alterations, such as protein, lipid, and DNA damage. Considering that the same ROS level can have a deleterious effect on the fertilizing oocyte or embryo at certain stages, and a positive effect at another stage of the development process, further studies need to be carried out to determine the rate of ROS that benefits the embryo and from what rate it starts to be harmful, this measured at each key phase of embryonic development.<\/jats:p>","DOI":"10.1017\/s0967199420000179","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:10:58Z","timestamp":1588050658000},"page":"255-269","source":"Crossref","is-referenced-by-count":46,"title":["Reactive oxygen species in reproduction: harmful, essential or both?"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-6017","authenticated-orcid":false,"given":"M.","family":"Jamil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Debbarh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aboulmaouahib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Aniq Filali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mounaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zarqaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Saadani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Louanjli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"S0967199420000179_ref319","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2419"},{"key":"S0967199420000179_ref318","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt036"},{"key":"S0967199420000179_ref312","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145585"},{"key":"S0967199420000179_ref311","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9831-x"},{"key":"S0967199420000179_ref303","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.12.019"},{"key":"S0967199420000179_ref301","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0696-2"},{"key":"S0967199420000179_ref300","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0466"},{"key":"S0967199420000179_ref298","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.03.016"},{"key":"S0967199420000179_ref297","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.01.008"},{"key":"S0967199420000179_ref295","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02959-X"},{"key":"S0967199420000179_ref292","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.077768"},{"key":"S0967199420000179_ref289","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jcp.22108","article-title":"Meiotic cell cycle arrest in mammalian oocytes","volume":"223","author":"Tripathi","year":"2010","journal-title":"J. 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