{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:10:06Z","timestamp":1778494206773,"version":"3.51.4"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Spermatogenesis is an androgen-dependent event, and testosterone is the major androgen source. The enzyme 5-alpha reductase converts testosterone to dihydrotestosterone (DHT) in testicular and peripheral tissues. Polymorphisms in genes encoding 5-alpha reductase may be associated with impaired male fertility. The present study aimed to investigate the relationship between 5-alpha reductase type 2 (<jats:italic>SRD5A2<\/jats:italic>) gene rs523349 polymorphism and non-obstructive azoospermia (NOA) in Turkish patients. The study included 75 NOA patients and 43 fertile men from Turkey. No significant relationship was found between <jats:italic>SRD5A2<\/jats:italic> gene rs523349 polymorphism and male infertility (<jats:italic>P<\/jats:italic> = 0.071). There was a statistically significant difference in total testosterone level and total testis volume between NOA patients and the control groups, however there was no significant difference between serum follicle-stimulating hormone and luteinizing hormone levels. Our results showed that <jats:italic>SRD5A2<\/jats:italic> gene rs523349 polymorphism was not associated with NOA in Turkish patients.<\/jats:p>","DOI":"10.1017\/s0967199420000544","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T08:27:41Z","timestamp":1602664061000},"page":"118-121","source":"Crossref","is-referenced-by-count":2,"title":["5-Alfa reductase type 2 (<i>SRD5A2<\/i>) gene rs523349 polymorphism is not associated with non-obstructive azoospermia in Turkish patients"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-297X","authenticated-orcid":false,"given":"Munevver","family":"Serdarogullari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-9572","authenticated-orcid":false,"given":"Onder","family":"Coban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zalihe","family":"Yarkiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Gulec Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Akdeniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgay","family":"Isbir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"S0967199420000544_ref13","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(Sup01)14"},{"key":"S0967199420000544_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70024-4"},{"key":"S0967199420000544_ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-37-3-448"},{"key":"S0967199420000544_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0138-6"},{"key":"S0967199420000544_ref16","doi-asserted-by":"publisher","DOI":"10.4161\/spmg.1.2.16956"},{"key":"S0967199420000544_ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/530121"},{"key":"S0967199420000544_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0443-x"},{"key":"S0967199420000544_ref20","unstructured":"IBM Corp. Released (2016). IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY: IBM Corp. Source: https:\/\/www-01.ibm.com\/support\/docview.wss?uid=swg21476197."},{"key":"S0967199420000544_ref7","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(Sup01)06"},{"key":"S0967199420000544_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2008.00350.x"},{"key":"S0967199420000544_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"S0967199420000544_ref17","unstructured":"WHO (2010). 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