{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:36:13Z","timestamp":1780097773303,"version":"3.54.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is a condition that affects fertility. There are two types of PCOS; the normal\/lean type and overweight\/obese type. The aim of this study was to assess baseline characteristics, ovarian response, quality of oocytes, embryos, pregnancy, implantation and live birth rates in normal\/lean and overweight\/obese patients with PCOS undergoing ICSI compared with patients without PCOS. This retrospective case\u2013control analytical study included 38 normal\/lean and 17 overweight\/obese patients with PCOS, and 98 normal\/lean and 17 overweight\/obese patients without PCOS. Parameters were observed based on baseline characteristics, ovarian response to dosage and duration of gonadotropin administered, number of oocytes, matured oocytes, fertilization rate, embryo quality and development, pregnancy, implantation and live birth rates. Basal serum luteinizing hormone in normal\/lean PCOS was significantly higher compared with non-PCOS groups. Total dosage of gonadotropin used was significantly lower in normal\/lean PCOS compared with other groups. End estradiol levels in normal\/lean PCOS was significantly higher compared with the non-PCOS groups. Number of follicles, retrieved oocytes and matured oocytes were significantly higher in PCOS groups compared with the non-PCOS groups. However, there were no differences in fertilized oocytes, cleavage, number of top-quality embryos, pregnancy, implantation, and live birth rates among groups. This present study suggests that normal\/lean PCOS requires lower gonadotropin dosages and that patients with PCOS have more follicles and oocytes compared with patients without PCOS, however the number of fertilized oocytes and embryos from patients with PCOS were the same as those from patients without PCOS and suggested that the quality of retrieved oocytes in PCOS might be compromised.<\/jats:p>","DOI":"10.1017\/s0967199420000830","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T08:06:53Z","timestamp":1610957213000},"page":"229-233","source":"Crossref","is-referenced-by-count":9,"title":["Impact of body mass index on intracytoplasmic sperm injection in women with polycystic ovary syndrome"],"prefix":"10.1017","volume":"29","author":[{"given":"Stanly","family":"Kamardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IGN Harry Wijaya","family":"Surya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Nyoman Bayu","family":"Mahendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IB Putra","family":"Adnyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anom","family":"Suardika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nono","family":"Tondohusodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-8138","authenticated-orcid":false,"given":"Jaqueline","family":"Sudiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"S0967199420000830_ref8","first-page":"1911","article-title":"The impact of endometriosis on IVF\/ICSI outcomes","volume":"6","author":"Dong","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"S0967199420000830_ref1","first-page":"92","volume-title":"Reproductive Endocrinology: An Update in Obstetrics and Gynecology","year":"1998"},{"key":"S0967199420000830_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogn.2015.10.001"},{"key":"S0967199420000830_ref23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.29252\/ijrm.16.8.529","article-title":"Influence of body mass index and polycystic ovarian syndrome on ICSI\/IVF treatment outcomes: A study conducted in Pakistani women","volume":"16","author":"Rehman","year":"2018","journal-title":"Int J Reprod Biomed (Yazd)"},{"key":"S0967199420000830_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.6.1086"},{"key":"S0967199420000830_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.035"},{"key":"S0967199420000830_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2012.10.003"},{"key":"S0967199420000830_ref6","first-page":"991","article-title":"Overweight and obesity adversely affect outcomes of assisted reproductive technologies in polycystic ovary syndrome patients","volume":"6","author":"Bu","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"S0967199420000830_ref5","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.1149"},{"key":"S0967199420000830_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2018.12.001"},{"key":"S0967199420000830_ref12","first-page":"5872","article-title":"Effect of overweight\/obesity on IVF-ET outcomes in chinese patients with polycystic ovary syndrome","volume":"7","author":"Huang","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"S0967199420000830_ref24","volume-title":"International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","author":"Teede","year":"2018"},{"key":"S0967199420000830_ref3","doi-asserted-by":"publisher","DOI":"10.4236\/ojemd.2016.61008"},{"key":"S0967199420000830_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61728-2"},{"key":"S0967199420000830_ref26","volume-title":"Polycystic Ovarian Syndrome and Hyperandrogenism","author":"Wilson","year":"2008"},{"key":"S0967199420000830_ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1514916"},{"key":"S0967199420000830_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.09.042"},{"key":"S0967199420000830_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.077"},{"key":"S0967199420000830_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219768.08249.b6"},{"key":"S0967199420000830_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/srep34538"},{"key":"S0967199420000830_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.024"},{"key":"S0967199420000830_ref14","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2016.15235"},{"key":"S0967199420000830_ref10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/00365510050216376","article-title":"Leptin and leptin binding activity in the preovulatory follicle of polycystic ovary syndrome patients","volume":"60","author":"Fedorcsak","year":"2000","journal-title":"Scand J Clin Lab Invest"},{"key":"S0967199420000830_ref22","unstructured":"Purnell, JQ (2018). Definitions, Classification, and Epidemiology of Obesity. 2018 Apr 12. In: Feingold, KR , Anawalt, B , Boyce, A , Chrousos, G , de Herder, WW , Dungan, K , Grossman, A , Hershman, JM , Hofland, HJ , Kaltsas, G , Koch, C , Kopp, P , Korbonits, M , McLachlan, R , Morley, JE , New, M , Purnell, J , Singer, F , Stratakis, CA , Trence, DL and Wilson, DP (eds). Endotext [Internet]. South Dartmouth (MA): MDText.com."},{"key":"S0967199420000830_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/srep19436"}],"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199420000830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T12:06:47Z","timestamp":1622722007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199420000830\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0967199420000830"],"URL":"https:\/\/doi.org\/10.1017\/s0967199420000830","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"value":"0967-1994","type":"print"},{"value":"1469-8730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]}}}