{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:11:26Z","timestamp":1778026286960,"version":"3.51.4"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the sperm obtained on pregnancy outcome remains to be explored. This study aimed to investigate the relationship between sperm motility with clinical outcome of PESA\u2013ICSI in infertile males with CBAVD. A cohort of 110 couples was enrolled. In total, 76 infertile males were included in the high motility group, while the remaining 34 males were placed in the low motility group. Clinical pregnancy, embryo implantation rate and live birth rate were included as the primary outcome. After all follow-ups, we found that the high motility group achieved higher normal fertilization rates, cleavage rates, transplantable embryo rates and high-quality embryo rates than those in low motility group (normal fertilization rate, 78.2 \u00b1 11.7% vs. 70.5 \u00b1 10.2%,<jats:italic>P<\/jats:italic>= 0.003; cleavage rate, 97.1 \u00b1 2.9% vs. 92.3 \u00b1 3.0%,<jats:italic>P<\/jats:italic>= 0.000; transplantable embryo rate, 66.8 \u00b1 14.9% vs. 58.6 \u00b1 12.6%,<jats:italic>P<\/jats:italic>= 0.009 and high-quality embryo rate, 49.9 \u00b1 10.5% vs. 40.5 \u00b1 11.2%,<jats:italic>P<\/jats:italic>= 0.000). Additionally, compared with the low motility group, the clinical pregnancy rates, embryo implantation rates, and live birth rates in the high motility group were significantly increased (pregnancy rate, 61.8% vs. 26.5%,<jats:italic>P<\/jats:italic>= 0.009; embryo implantation rate, 36.5% vs. 18.0%,<jats:italic>P<\/jats:italic>= 0.044; live birth rate, 55.3% vs. 17.6%,<jats:italic>P<\/jats:italic>= 0.000). We concluded that the motility of sperm obtained by PESA affected the clinical outcome of ICSI in infertile males with CBAVD.<\/jats:p>","DOI":"10.1017\/s0967199421000587","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:20:40Z","timestamp":1627384840000},"page":"234-238","source":"Crossref","is-referenced-by-count":5,"title":["Relationship of sperm motility with clinical outcome of percutaneous epididymal sperm aspiration\u2013intracytoplasmic sperm injection in infertile males with congenital domestic absence of vas deferens: a retrospective study"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-7871","authenticated-orcid":false,"given":"Zhong","family":"Jixiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Lianmei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuo","family":"Yanghua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Huiying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"S0967199421000587_ref3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/oxfordjournals.humrep.a138609","article-title":"Live birth resulting from in-office vas deferens sperm retrieval combined with natural-cycle insemination","volume":"9","author":"Buch","year":"1994","journal-title":"Hum Reprod"},{"key":"S0967199421000587_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65193-2"},{"key":"S0967199421000587_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev015"},{"key":"S0967199421000587_ref6","doi-asserted-by":"crossref","first-page":"S342","DOI":"10.1016\/j.fertnstert.2007.07.1154","article-title":"ICSI with cryopreserved epididymal and testicular sperm can yield high clinical pregnancy and implantation rates strategies to improve success","volume":"88","author":"Desai","year":"2007","journal-title":"Fertil Steril"},{"key":"S0967199421000587_ref12","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/humrep\/13.4.1111","article-title":"Testicular sperm aspiration (TESA): the appropriate technique","volume":"13","author":"Gorgy","year":"1998","journal-title":"Hum Reprod"},{"key":"S0967199421000587_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)02212-X"},{"key":"S0967199421000587_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18881-2_2"},{"key":"S0967199421000587_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.04.010"},{"key":"S0967199421000587_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"S0967199421000587_ref13","first-page":"66","article-title":"Physiological intra-cytoplasmic sperm injection (PICSI) outcomes after oral pretreatment and semen incubation with myo-inositol in oligoasthenoteratozoospermic men: results from a prospective, randomized controlled trial","volume":"21","author":"Korosi","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"S0967199421000587_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02068873"},{"key":"S0967199421000587_ref15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1196\/annals.1320.017","article-title":"The role of carnitine in the male reproductive system","volume":"1033","author":"Ng","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"S0967199421000587_ref20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/humrep\/17.2.362","article-title":"Outcome of conventional IVF and ICSI on sibling oocytes in mild male factor infertility","volume":"17","author":"Plachot","year":"2002","journal-title":"Hum Reprod"},{"key":"S0967199421000587_ref18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0015-0282(97)90844-X","article-title":"Successful fertilization and pregnancy with non-motile sperm in ICSI program","volume":"1997","author":"Oum","year":"1997","journal-title":"Fertil Steril"},{"key":"S0967199421000587_ref33","doi-asserted-by":"publisher","DOI":"10.1111\/and.13175"},{"key":"S0967199421000587_ref21","first-page":"645","article-title":"Relationship between sperm chromatin status and ICSI outcome in men with obstructive azoospermia and unexplained infertile normozoospermia","volume":"52","author":"Sadeghi","year":"2011","journal-title":"Roman J Morphol Embryol"},{"key":"S0967199421000587_ref7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/mutage\/15.1.61","article-title":"Glutathione and hypotaurine in vitro: Effects on human sperm motility, DNA integrity and production of reactive oxygen species","volume":"15","author":"Donnelly","year":"2000","journal-title":"Mutagenesis"},{"key":"S0967199421000587_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0374-1"},{"key":"S0967199421000587_ref4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5653\/cerm.2017.44.3.132","article-title":"ICSI significantly improved the pregnancy rate of patients with a high sperm DNA fragmentation index","volume":"44","author":"Chi","year":"2017","journal-title":"Clin Exp Reprod Med"},{"key":"S0967199421000587_ref25","first-page":"704","article-title":"Seminal plasma levocarnitine significantly correlated with semen quality","volume":"14","author":"Tang","year":"2008","journal-title":"Zhonghua Nan Ke Xue"},{"key":"S0967199421000587_ref31","first-page":"253","article-title":"Short-term medication of l-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia","volume":"18","author":"Wu","year":"2012","journal-title":"Zhonghua Nan Ke Xue"},{"key":"S0967199421000587_ref22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1365-2605.2001.00307.x","article-title":"Predictive factors of successful testicular sperm recovery in non-obstructive azoospermia patients","volume":"24","author":"Seo","year":"2001","journal-title":"Int J Androl"},{"key":"S0967199421000587_ref16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/j.1939-4640.1996.tb01773.x","article-title":"How does poor motility alter sperm fertilizing ability?","volume":"17","author":"Olds-Clarke","year":"1996","journal-title":"J Androl"},{"key":"S0967199421000587_ref5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fertnstert.2013.03.011","article-title":"In vitro fertilization-intracytoplasmic sperm injection outcome in patients with a markedly high DNA fragmentation index (>50%)","volume":"100","author":"Dar","year":"2013","journal-title":"Fertil Steril"},{"key":"S0967199421000587_ref17","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1530\/REP-18-0011","article-title":"Development of ICSI","volume":"156","author":"O\u2019Neill","year":"2018","journal-title":"Reproduction"},{"key":"S0967199421000587_ref28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J Assist Reprod Genet"},{"key":"S0967199421000587_ref30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/j.1939-4640.2003.tb02642.x","article-title":"Effect on clinical outcome of the interval between collection of epididymal and testicular spermatozoa and intracytoplasmic sperm injection in obstructive azoospermia","volume":"24","author":"Wood","year":"2003","journal-title":"J Androl"},{"key":"S0967199421000587_ref9","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.theriogenology.2006.04.037","article-title":"Analysis of different factors influencing the intracytoplasmic sperm injection (ICSI) yield in pigs","volume":"66","author":"Garc\u00eda-Rosell\u00f3","year":"2006","journal-title":"Theriogenology"},{"key":"S0967199421000587_ref23","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/etc.2957","article-title":"Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm","volume":"34","author":"Singh","year":"2015","journal-title":"Environ Toxicol Chem"},{"key":"S0967199421000587_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.11.2371"},{"key":"S0967199421000587_ref27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF02070145","article-title":"Cumulative experience of percutaneous epididymal sperm aspiration (PESA) with intracytoplasmic sperm injection","volume":"13","author":"Tsirigotis","year":"1996","journal-title":"J Assist Reprod Genet"},{"key":"S0967199421000587_ref1","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/humrep\/16.7.1424","article-title":"Ongoing twin pregnancy after ICSI of PESA-retrieved spermatozoa into in-vitro matured oocytes: Case report","volume":"16","author":"Abdul-Jalil","year":"2001","journal-title":"Hum Reprod"},{"key":"S0967199421000587_ref14","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.12968\/bjon.2016.25.18.S35","article-title":"Male infertility: an overview of causes and treatment options","volume":"25","author":"Leaver","year":"2016","journal-title":"Br J Nurs"}],"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199421000587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T14:25:58Z","timestamp":1699280758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199421000587\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0967199421000587"],"URL":"https:\/\/doi.org\/10.1017\/s0967199421000587","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"value":"0967-1994","type":"print"},{"value":"1469-8730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,27]]}}}