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PCOS is associated with 40% of female infertility and endometrial cancer. The WNT\/\u03b2-catenin signalling transduction pathway regulates aspects of cell proliferation, migration and cell fate determination in the tissue along with early embryonic development and controls the proper activation of the female reproductive system, along with regulating hormonal activity in ovarian granulosa cells. In the current study, we investigated the expression profiles of WNT\/\u03b2-catenin signalling pathway genes (<jats:italic>AXIN2<\/jats:italic>, <jats:italic>FZD4<\/jats:italic>, <jats:italic>TCF4<\/jats:italic>, <jats:italic>WNT3<\/jats:italic>, <jats:italic>WNT4<\/jats:italic>, <jats:italic>WNT5A<\/jats:italic>, <jats:italic>WNT7A<\/jats:italic>, <jats:italic>WNT1<\/jats:italic>, <jats:italic>APC<\/jats:italic>, <jats:italic>GSK3B<\/jats:italic> and <jats:italic>\u03b2-catenin<\/jats:italic>) in a total of 13 oocyte samples. Seven of these samples were from polycystic women and six were from healthy women. The results of this study displayed the absence of expression of <jats:italic>AXIN2<\/jats:italic>, <jats:italic>FZD4<\/jats:italic>, <jats:italic>TCF4<\/jats:italic>, <jats:italic>WNT5A<\/jats:italic>, <jats:italic>WNT3<\/jats:italic>, <jats:italic>WNT4<\/jats:italic> and <jats:italic>WNT7A<\/jats:italic> genes in ovaries from women with PCOS and from healthy women. While <jats:italic>APC<\/jats:italic> and <jats:italic>\u03b2-catenin<\/jats:italic> expression levels were similar in the oocytes of both patients and controls, conversely, <jats:italic>WNT1<\/jats:italic> and <jats:italic>GSK3\u03b2<\/jats:italic> genes both showed elevated expression in the oocytes of patients with PCOS, therefore suggesting an association between aberrant expression of <jats:italic>WNT1<\/jats:italic> and <jats:italic>GSK3\u03b2<\/jats:italic> and the pathogenesis of PCOS. The observations of the current study could be helpful to provide evidence regarding the pathogenesis of PCOS and its treatment.<\/jats:p>","DOI":"10.1017\/s0967199422000028","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T14:08:48Z","timestamp":1648735728000},"page":"536-542","source":"Crossref","is-referenced-by-count":18,"title":["The expression profile of WNT\/\u03b2-catanin signalling genes in human oocytes obtained from polycystic ovarian syndrome (PCOS) patients"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-5868","authenticated-orcid":false,"given":"Aya Badeea","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan \u2019Mohammad 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