{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:10Z","timestamp":1786999570360,"version":"build-2736575974"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The purpose of this retrospective study was to optimize the transplantation strategy for women of advanced maternal age to achieve live births within the shortest time. Data were collected from patients older than 40 years who underwent assisted reproductive therapy at our centre from 1 January 2009 to 31 December 2019. In total, 1023 cases of fresh cleavage embryo transfer (CET) cycles, 280 cases of frozen\u2013thawed blastocyst transfer (FBT) cycles, and 26 cases of frozen\u2013thawed CET (FCET) cycles were included. The main outcome was the live birth rate (LBR). The secondary outcomes were the clinical pregnancy rate (CPR) and neonatal outcomes. Multivariable logistic regression was performed to adjust for confounding factors. The blastocyst formation rate of patients older than 40 years was 23.5%, the freezing cycle rate was 19.8%, and the fresh-embryo transfer rate was 83.0%. The implantation rate, CPR, and LBR were significantly different among the CET, FCET, and FBT groups. There were no significant differences in multiple pregnancies and abortion rates among the groups, and neonatal outcomes were similar. Multivariate logistic regression analysis showed that, compared with the CET group, LBR did not increase in the FCET group, whereas LBR increased in the FBT group. For patients older than 40 years when having approximately eight embryos after fertilization, blastocyst transfer can be considered after fully discussing the advantages and disadvantages of blastocyst culture. Alternatively, CET can be performed first, followed by FBT if the cleavage embryo transfer is unsuccessful.<\/jats:p>","DOI":"10.1017\/s0967199422000259","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T04:11:15Z","timestamp":1658376675000},"page":"781-789","source":"Crossref","is-referenced-by-count":4,"title":["Strategy for embryo transfer to improve pregnancy outcomes in advanced maternal age"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7241-7719","authenticated-orcid":false,"given":"Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingran","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"S0967199422000259_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00518-5"},{"key":"S0967199422000259_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1257-7"},{"key":"S0967199422000259_ref20","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1332175"},{"key":"S0967199422000259_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu001"},{"key":"S0967199422000259_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.127"},{"key":"S0967199422000259_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32843-5"},{"key":"S0967199422000259_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0062-6"},{"key":"S0967199422000259_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.044"},{"key":"S0967199422000259_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.01.004"},{"key":"S0967199422000259_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02077-5"},{"key":"S0967199422000259_ref4","first-page":"229","article-title":"Reproductive outcomes of women aged 40 and older undergoing IVF with donor sperm","volume":"36","author":"Bortoletto","year":"2021","journal-title":"Human Reproduction"},{"key":"S0967199422000259_ref16","first-page":"CD002118","article-title":"Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology","volume":"6","author":"Glujovsky","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0967199422000259_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.01.041"},{"key":"S0967199422000259_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.029"},{"key":"S0967199422000259_ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053524"},{"key":"S0967199422000259_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem339"},{"key":"S0967199422000259_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.038"},{"key":"S0967199422000259_ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0774-5"},{"key":"S0967199422000259_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0255-4"},{"key":"S0967199422000259_ref40","first-page":"CD011184","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2","author":"Zaat","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0967199422000259_ref41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207340"},{"key":"S0967199422000259_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1092-2"},{"key":"S0967199422000259_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12355"},{"key":"S0967199422000259_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.003"},{"key":"S0967199422000259_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199415000696"},{"key":"S0967199422000259_ref21","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2018.1501114"},{"key":"S0967199422000259_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.02.107"},{"key":"S0967199422000259_ref42","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey044"},{"key":"S0967199422000259_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2017.12.003"},{"key":"S0967199422000259_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey388"},{"key":"S0967199422000259_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.09.019"},{"key":"S0967199422000259_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.023"},{"key":"S0967199422000259_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.058"},{"key":"S0967199422000259_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.022"},{"key":"S0967199422000259_ref33","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: Systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Human Reproduction Update"},{"key":"S0967199422000259_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew183"},{"key":"S0967199422000259_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.05.027"},{"key":"S0967199422000259_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.032"},{"key":"S0967199422000259_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-13-3"},{"key":"S0967199422000259_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01641-4"},{"key":"S0967199422000259_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez133"},{"key":"S0967199422000259_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.09.011"}],"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199422000259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:48:36Z","timestamp":1668743316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199422000259\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0967199422000259"],"URL":"https:\/\/doi.org\/10.1017\/s0967199422000259","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"value":"0967-1994","type":"print"},{"value":"1469-8730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]}}}