{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:53:50Z","timestamp":1761710030150,"version":"3.40.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The live birth rate following embryo transfer is comparable between spontaneous, stimulated and artificial cycles. However, the pregnancy loss rate appears elevated with hormonal therapy, possibly due to luteal insufficiency. This study aimed to determine whether the serum progesterone level on transfer day differed according to the endometrial preparation method for frozen embryo transfer (FET). Twenty spontaneous cycles (SC), 27 ovarian stimulation cycles (OS) and 65 artificial cycles (AC) were retrospectively studied from May to December 2019 in a single French hospital. The primary endpoint was the level of serum progesterone on the day of FET between the three endometrial preparation methods. The mean serum progesterone level on transfer day was 29.47 ng\/ml in the OS group versus 20.03 ng\/ml in the SC group and 14.32 ng\/ml AC group (<jats:italic>P<\/jats:italic> &lt; 0.0001). Progesterone levels remained significantly different after logistic regression on age and anti-M\u00fcllerian hormone (AMH) level. There was no significant difference in demographic and hormone characteristics (age, body mass index, embryo stage of embryo, type of infertility, basal follicle stimulating hormone, luteinizing hormone, estradiol and AMH levels), endometrial thickness, number and type of embryos transferred, duration of infertility, pregnancy rate, live birth rate and pregnancy loss rate. No difference was found in serum progesterone levels between clinical pregnancy with fetal heartbeat and no clinical pregnancy (no pregnancy or pregnancy loss, 17.49 ng\/ml vs 20.83 ng\/ml, respectively, <jats:italic>P<\/jats:italic> = 0.07). The lower serum progesterone level found on FET day in the AC group should be further investigated to see whether this difference has a clinical effect on the live birth rate.<\/jats:p>","DOI":"10.1017\/s0967199423000163","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:24:49Z","timestamp":1684391089000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of serum progesterone levels on the day of frozen embryo transfers according to type of endometrial preparation: a single centre, retrospective study"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-5542","authenticated-orcid":false,"given":"Olivier","family":"Pouget","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakarya","family":"Zemmache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Alsawaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Zuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Bonneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Laure","family":"Tailland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Nobre Meirinhos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rougier-Maillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Sigala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Poirey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Huberlant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"S0967199423000163_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12043"},{"key":"S0967199423000163_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev224"},{"key":"S0967199423000163_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.07.002"},{"key":"S0967199423000163_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.01.006"},{"key":"S0967199423000163_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.11.026"},{"key":"S0967199423000163_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa322"},{"key":"S0967199423000163_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex285"},{"key":"S0967199423000163_ref25","first-page":"CD003414","article-title":"Cycle regimens for frozen-thawed embryo transfer","volume":"7","author":"Ghobara","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0967199423000163_ref7","unstructured":"Labarta, E (2019). A large prospective trial in unselected population confirms that low serum progesterone on the day of embryo transfer impairs pregnancy outcome in artificial cycles. Oral presentation O-173. 35th Annual ESHRE Meeting, Vienna, Austria."},{"key":"S0967199423000163_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.102030"},{"key":"S0967199423000163_ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3937"},{"key":"S0967199423000163_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.10.040"},{"key":"S0967199423000163_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.736560"},{"key":"S0967199423000163_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac007"},{"key":"S0967199423000163_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det361"},{"key":"S0967199423000163_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey242"},{"key":"S0967199423000163_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3396-0"},{"key":"S0967199423000163_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex023"},{"key":"S0967199423000163_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"S0967199423000163_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.01.007"},{"key":"S0967199423000163_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.010"},{"key":"S0967199423000163_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex316"},{"key":"S0967199423000163_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12757"},{"key":"S0967199423000163_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0549-9"},{"key":"S0967199423000163_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1058"},{"key":"S0967199423000163_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.007"},{"key":"S0967199423000163_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.08.022"}],"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199423000163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T08:30:11Z","timestamp":1688632211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199423000163\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0967199423000163"],"URL":"https:\/\/doi.org\/10.1017\/s0967199423000163","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"type":"print","value":"0967-1994"},{"type":"electronic","value":"1469-8730"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}