{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:19:19Z","timestamp":1787937559240,"version":"build-2784847793"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>At this time, with advances in medical science, many cancers and chronic diseases are treatable, but one of their side effects is infertility. Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor, suggesting that the role of kisspeptin in direct control of ovarian function includes follicle growth and steroid production. In this study, the effect of kisspeptin on improving the quality and results for human ovarian follicles was investigated. A section of ovary was removed laparoscopically from women between 20 and 35 years of age (<jats:italic>n<\/jats:italic> = 12). Pieces were divided randomly into two groups, control and treatment (with 1 \u03bcM kisspeptin). Real-time PCR was performed for <jats:italic>GDF9<\/jats:italic>, <jats:italic>BMP15<\/jats:italic> and <jats:italic>mTOR<\/jats:italic> gene expression assessments. Western blotting was carried out to measure AKT and FOXO3a protein expression. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey\u2019s test; means were considered significantly different at a <jats:italic>P<\/jats:italic>-value &lt; 0.05. During treatment with the kisspeptin group, maturity genes are expressed. Therefore, kisspeptin is an effective substance to improve the quality of the human ovarian medium as it increases the maturity of follicles.<\/jats:p>","DOI":"10.1017\/s0967199423000527","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T04:41:06Z","timestamp":1702615266000},"page":"66-70","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Effects of kisspeptin on the maturation of human ovarian primordial follicles <i>in vitro<\/i>"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-6482","authenticated-orcid":false,"given":"Fatemeh","family":"Rezaei-Tazangi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kooshesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Tayyebiazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Taghizabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-1302","authenticated-orcid":false,"given":"Anahita","family":"Tavakoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Hassanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Aliakbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Kharazinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali-Mohammad","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"S0967199423000527_ref15","doi-asserted-by":"crossref","first-page":"8538","DOI":"10.1038\/s41598-017-09005-7","article-title":"Vitrification versus slow freezing for human ovarian tissue cryopreservation: A systematic review and meta-analysis","volume":"7","author":"Shi","year":"2017","journal-title":"Scientific Reports"},{"key":"S0967199423000527_ref17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1017\/S0967199418000138","article-title":"Human cumulus cell sensitivity to vitrification, an ultrastructural study","volume":"26","author":"Taghizabet","year":"2018","journal-title":"Zygote"},{"key":"S0967199423000527_ref20","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S1470-2045(14)70334-1","article-title":"Fertility preservation for girls and young women with cancer: Population-based validation of criteria for ovarian tissue cryopreservation","volume":"15","author":"Wallace","year":"2014","journal-title":"Lancet. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}