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B6C3F1Crl (C57BL\/6N \u00d7 C3H\/HeN) male and female mice were selected for the first part of the experiments and were analyzed for body weight and fat weight after administration of the MIF intervention, followed by analysis of sperm counts and activation and embryo numbers. Subsequently, two strains of mice, C57BL\/6NCrl and BALB\/cJRj, were selected and administered MIF to observe the presence or absence of vaginal plugs for the purposes of mating success, sperm and oocyte quality, pregnancy outcome, fertility status and <jats:italic>in vitro<\/jats:italic> fertilization (IVF). Our results showed a significant reduction in body weight and fat content in mice receiving MIF intervention in B6C3F1Crl mice. Comparing the reproduction of the two strains of mice. However, the number of litters was increased in all MIF interventions in C57BL\/6NCrl, but not statistically significant. In BALB\/cJRj, there was a significant increase in the number of pregnant females as well as litter size in the MIF treatment group, as well as vaginal plugs, and IVF. There was also an increase in sperm activation and embryo number and the MIF intervention significantly increased sperm count and activation. Our results suggest that MIF interventions may be beneficial for reproduction in mice.<\/jats:p>","DOI":"10.1017\/s0967199424000108","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:33:56Z","timestamp":1715592836000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of mice with maternal intermittent fasting to improve the fertilization rate and 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