{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:14:33Z","timestamp":1785417273248,"version":"3.56.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"unspecified","delay-in-days":50,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Infertility aetiology has been shown to be related to reproductive outcomes in the wide reproductive age range. The aim of this study was to examine young women\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertilization (IVF) cycle outcomes according to age and infertility cause. This retrospective cohort study was comprised of 305 couples with a female partner aged 17\u201325 years with either male or female infertility that underwent a fresh IVF cycle between 2003 and 2020. Comparison according to age groups 17\u201322 years (\n                    <jats:italic>n<\/jats:italic>\n                    = 117) and 23\u201325 years (\n                    <jats:italic>n<\/jats:italic>\n                    = 188) showed similar outcomes, except for higher rates of 3 pronuclei (PN) embryos in the younger group. However, allocation to groups by infertility aetiology - male factor (MF) (\n                    <jats:italic>n<\/jats:italic>\n                    = 241) vs. female factor (FF) (\n                    <jats:italic>n<\/jats:italic>\n                    = 64) demonstrated lower fertilization rate in the FF vs. MF group (58% vs. 63%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.049) and higher percent of 1PN and 3PN embryos (0.7% vs. 0.2% and 0.7% vs. 0.1%,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001 for both). Chemical pregnancy and live-birth rate were significantly higher in the MF vs. FF group (48.9% vs. 29.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02 and 41.9% vs. 11.0%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.038). The only parameter associated with live birth rate in a logistic regression analysis was male infertility aetiology (\n                    <jats:italic>OR<\/jats:italic>\n                    = 2.17,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.038). Young couples undergoing IVF cycles due to female factor infertility have poorer reproductive outcomes compared to male factor-related infertility and higher rates of 1PN and 3PN embryos.\n                  <\/jats:p>","DOI":"10.1017\/s0967199426100306","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:40:11Z","timestamp":1774266011000},"page":"4-11","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    fertilization outcomes in young women and their association with male and female infertility aetiology"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-4560","authenticated-orcid":false,"given":"Gilad","family":"Karavani","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cqmqj90","id-type":"ROR","asserted-by":"publisher"}],"name":"Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiila","family":"Bauch","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Schachter-Safrai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cqmqj90","id-type":"ROR","asserted-by":"publisher"}],"name":"Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Imbar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cqmqj90","id-type":"ROR","asserted-by":"publisher"}],"name":"Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Ban-Meir","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cqmqj90","id-type":"ROR","asserted-by":"publisher"}],"name":"Hadassah Ein-Kerem Medical Center and Faculty of Medicine, Hebrew University of Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"S0967199426100306_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)05291-9"},{"key":"S0967199426100306_ref9","doi-asserted-by":"publisher","DOI":"10.1080\/14647270600636269"},{"key":"S0967199426100306_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF01131703"},{"key":"S0967199426100306_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137041"},{"key":"S0967199426100306_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev336"},{"key":"S0967199426100306_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2014.968104"},{"key":"S0967199426100306_ref39","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den135"},{"key":"S0967199426100306_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.032"},{"key":"S0967199426100306_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082249"},{"key":"S0967199426100306_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.2.321"},{"key":"S0967199426100306_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.2.141"},{"key":"S0967199426100306_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq015"},{"key":"S0967199426100306_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135964"},{"key":"S0967199426100306_ref3","doi-asserted-by":"publisher","DOI":"10.1023\/B:JARG.0000027018.02425.15"},{"key":"S0967199426100306_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0570-7"},{"key":"S0967199426100306_ref40","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199405003382"},{"key":"S0967199426100306_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-006-9082-9"},{"key":"S0967199426100306_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01494-x"},{"key":"S0967199426100306_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61057-7"},{"key":"S0967199426100306_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93060-M"},{"key":"S0967199426100306_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq032"},{"key":"S0967199426100306_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm048"},{"key":"S0967199426100306_ref22","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022528915761"},{"key":"S0967199426100306_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08217.x"},{"key":"S0967199426100306_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803072"},{"key":"S0967199426100306_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5735"},{"key":"S0967199426100306_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep085"},{"key":"S0967199426100306_ref28","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1042958"},{"key":"S0967199426100306_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.008"},{"key":"S0967199426100306_ref13","unstructured":"Harris, K. , Fitzgerald, O. , Paul, R.C. , Macaldowie, A. , Lee, E. and Chambers, G.M. (2016) Assisted reproductive technology in Australia and New Zealand 2014. Sydney: National Perinatal Epidemiology and Statistics Unit, the University of New South Wales."},{"key":"S0967199426100306_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem183"},{"key":"S0967199426100306_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01694-w"},{"key":"S0967199426100306_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9499-z"},{"key":"S0967199426100306_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.004"},{"key":"S0967199426100306_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9443-2"},{"key":"S0967199426100306_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)35087-3"},{"key":"S0967199426100306_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172456"},{"key":"S0967199426100306_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00552-X"},{"key":"S0967199426100306_ref38","volume-title":"Assisted Reproductive Technology in Australia and New Zealand 2008","author":"Wang","year":"2004"},{"key":"S0967199426100306_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91205-M"}],"container-title":["Zygote"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0967199426100306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:44:22Z","timestamp":1776336262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0967199426100306\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0967199426100306"],"URL":"https:\/\/doi.org\/10.1017\/s0967199426100306","relation":{},"ISSN":["0967-1994","1469-8730"],"issn-type":[{"value":"0967-1994","type":"print"},{"value":"1469-8730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}